McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to superior quality, cost-effective mental health services in the Boston area, Massachusetts and beyond. Since 1811, McLean Hospital has been a world leader in the treatment of mental illness and chemical dependency, research into the cause of mental illness and the training of generations of mental health care providers. McLean's multidisciplinary programs treat a broad range of psychiatric illnesses across the full continuum of care.
The Translational Neuroscience Laboratory (PI: Sabina Berretta) and the Translational Molecular Genomics Laboratory (PI: Torsten Klengel) at McLean Hospital seek a scientifically minded individual with excellent organization skills and attention to detail to join our teams as a technical research assistant (RA). The RA will, under general supervision, assist in research investigating the molecular mechanisms of brain disorders in the mammalian brain to gain further understanding of debilitating human psychiatric disorders such as Schizophrenia, Bipolar Disorder, Depression and PTSD, as well as neurological disorders such as Huntington's disease. This role will include dissections of human brain samples, molecular/wet lab and data driven approaches. Applicants should have a strong interest in preclinical as well as translational neuroscience. This position requests a two year committment.
The Berretta Lab focuses on the neurobiology of psychiatric disorders, focusing on their molecular and genetic underpinnings. Dr. Berretta is also the Director of the Harvard Brain Tissue Resource Center. Her lab utilizes human postmortem tissue in combination with a diverse set of methods, including histochemistry, immunocytochemistry and in situ hybridization in combination with light, fluorescence and confocal microscopy to investigate the extracellular matrix in the brain. The Klengel Lab focuses on molecular genomics of major psychiatric disorders with an emphasis on epigenetic and transcriptional regulation. The Klengel Lab has a highly translational approach studying psychiatric disorders in animal models and humans using genomic technologies, in-vitro models and molecular assays. Both labs maintain a highly interactive collaboration sharing expertise and ideas.
Working under the general supervision of a Senior Technical Research Assistant, Manager or Principal Investigator and following established policies and procedures, conducts a variety of routine experiments where methodologies are clearly established. Calculates, transcribes and analyzes data using basic statistics. May perform literature searches under direction of supervisor.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Process tissue samples (including dissecting postmortem human brain samples, sectioning with a microtome/cryostat, and immunohistochemistry)
Process clinical data including digitalization of paper documents
Perform DNA, RNA and protein extraction and analysis techniques (including western blots, PCR and qPCR)
Run statistical analyses on collected data
Perform general lab upkeep, such as preparing shared solutions and maintaining a clean and tidy work environment
Manage email and schedule
Perform all other duties as assigned.
All McLean team members are expected to consistently demonstrate our values of integrity, compassion, respect, diversity, teamwork, excellence and innovation in their work activities and interactions.
Professional interpersonal and communication skills.
Meticulous handling of sensitive data with regard to data safety and protection
Great organizational skills, detail oriented.
Ability to methodically record data and to analyze data using basic statistics.
Ability to perform a variety of routine tests and prioritize work.
Adequate computer skills required.
Prior wet lab research experiences are desired but not mandatory
BS or BA in a biological/physical science required.
Previous lab experience and leadership experience preferred.
All employees must possess basic computer skills to use a variety of electronic or online systems for communication, clinical and administrative purposes.
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