Technical Expert (Pbpk)

Syngenta Global Greensboro , NC 27395

Posted 3 months ago

About Syngenta

Syngenta is a leading agriculture company helping to improve global food security by enabling millions of farmers to make better use of available resources. Through world class science and innovative crop solutions, our 28,000 people in over 90 countries are working to transform how crops are grown. We are committed to rescuing land from degradation, enhancing biodiversity and revitalizing rural communities.

About this Job:

Based at our Greensboro site, you will be part of our North America Human Safety team. We are looking for a key scientific contributor within the Human Safety function of Product Safety and providing pharmacokinetic expertise to project teams, toxicologists and other functional areas as required. You will be responsible for protocol design, input for hypothesis-driven pharmacokinetic / toxicokinetic studies, evaluating data, and authoring company reports.

You will enjoy working with other scientific functions, being the subject matter expert, sharing your knowledge and guiding colleagues to address PBPK and ADME-related issues, and provide guidance on the appropriate use of these data for decision making purposes about compound progression.

We are looking for an experienced scientist who will to take responsibility for the design, conduct and interpretation of mechanistic in vivo and in vitro pharmacokinetic studies. Employing preclinical PBPK/PD models for the establishment of concentration-effect relationships, including in vitro to in vivo extrapolation and the projection of human exposure profiles to aid in the early identification of possible development risks and/or opportunities for improvements in risk assessments.

Essential Duties & Responsibilities:

  • Manage studies placed with external suppliers to ensure delivery of data of the appropriate quality to time and cost

  • Coordinate the delivery of studies conducted internally or externally to ensure project needs are met

  • Independently provide technical assistance to external suppliers, where appropriate, to facilitate transfer of technical know-how

  • Using your knowledge and expertise, interpret the data ensuring the appropriate questions have been answered and communicate the meaning of data and its implication to the project

  • Through participation in project teams contribute to key decisions and aid compound selection

  • Work with colleagues in other functions to support the use of ADME data sets to optimize toxicology study design and overall understanding of the compound's behavior in vivo

  • Identify opportunities for improvement/further development of existing capability, e.g. in vitro to in vivo extrapolation, use of in silico tools, and PBPK models

Education & Experience:

  • Requires a PhD (or equivalent work experience) in biological or chemical sciences

  • A fundamental understanding of compound discovery and development in an industrial setting and the utility of pharmacokinetics in this process

  • Background knowledge of mammalian toxicology studies and objectives

  • Training and hands-on experience in pharmacokinetics and basic knowledge in mechanistic PK/PD (TK/TD) modelling and an ability to design, supervise, and interpret various types of mechanistic ADME/PK and TK studies

  • Proficiency in the development/optimization of new/existing experimental models to support hypothesis-driven pharmacokinetic research

  • Prior experience with PK analysis (non-compartment & multi-compartment modelling) and a demonstrated ability to work with modelling tools (e.g., NONMEM, Phoenix, GastroPlus, Simcyp)

  • Experience working in multi-disciplinary project teams

  • Experience accessing services through third-party organizations

What We Offer:

  • Full Benefit Package (Medical, Dental & Vision) that starts your first day

  • 401k plan with company match, Profit Sharing & Retirement Savings Contribution

  • Paid Vacation, 12 Paid Holidays, Maternity and Paternity Leave, Education Assistance, Wellness Programs, Corporate Discounts among others

  • A culture that promotes work/life balance, celebrates diversity and offers numerous family oriented events throughout the year

Syngenta is an Equal Opportunity Employer and does not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity, marital or veteran status, disability, or any other legally protected status.

Syngenta Contact Information:

Family and Medical Leave Act (FMLA)

(http://www.dol.gov/whd/regs/compliance/posters/fmla.htm)

Equal Employment Opportunity Commission's (EEOC)

(http://webapps.dol.gov/elaws/firststep/poster_direct.htm)

Employee Polygraph Protection Act (EPPA)

(http://www.dol.gov/whd/regs/compliance/posters/eppa.htm)


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Technical Expert (Pbpk)

Syngenta Global