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The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions. Viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery.
Concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. Specifically, we are studying cellular proteins required for both influenza A and retrovirus/HIV infection. additionally, we are investigating novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses.
The scientists in the Chanda lab are also looking to find known drugs that can inhibit the Covid-19 virus. The approach they are taking, known as drug repositioning, can cut development time dramatically. Since they are looking at FDA-approved drugs that are proven to be safe in humans, these medicines could rapidly get to people infected with the virus. If successful, drug repositioning will likely be the fastest path to find a therapeutic solution for the virus.
A Staff Scientist position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K.
Chanda, as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, T cell biology, and virus-host interactions to discover novel druggable targets and small molecule agonists or inhibitors. This position will lead projects focused on generating new systems and technologies for high throughput functional genetic level and small molecule screens. The Staff Scientist will play an important intellectual, technical, and scientific role in leading projects focused on elucidating novel factors involved in the interplay between virus and host innate immune factors, and understanding their therapeutic implications in inflammatory, autoimmune, infectious disease, and cancer.
In addition, the candidate will interface with external collaborators, mentor direct reports, and lead grant-writing efforts. Position is a fully supported non-tenure track position with the responsibility of leading a team of scientists, while retaining the ability to conduct independent research. Visit the Chanda lab website to learn more: The Chanda Lab
View these videos and links on the current research in the Chanda lab:
Discovery of SARS-CoV-2 antiviral drugs (Nature)
Covid-19 antibody research efforts
Meet Scientists on the front line with coronavirus
Finding a drug for COVID-19
10 News Sumit Chanda Interview
HIV functional cure
Works with current laboratory personnel on collaborative projects to develop novel modulators of nuclear receptors as guided by project plans
Independently develops and implements new projects
Directs the work of technical staff working on assigned projects
Contributes and assists with preparation of grant applications for new funding
Must contribute to publish scientific papers
Sanford Burnham Prebys Medical Discovery Institute