The Gastrointestinal Medical Oncology department is a team of highly specialized medical oncologists, scientists, physician assistants and research nurses who treat gastrointestinal malignancies, including cancers of the liver, bile duct, gallbladder, pancreas, large and small bowel, stomach, esophagus and rare tumors.
Our mission is to deliver the highest quality patient care by providing the most advanced medical therapies and opportunities to participate in clinical trials, with the goal of improving survival and quality of life. Research scientists are working to find better therapies, as well as more accurate diagnosis and screening procedures to detect GI cancers in their earliest stages. Fellowship and residency programs are available to train future generations of gastrointestinal oncologists.
The primary purpose of the Sr Research Scientist is to provide technical expertise and experience through coordinating, designing and carrying out translational research projects under the direction of Dr. Scott Kopetz. All projects will be conducted with IRB approval and in compliance with institutional regulatory requirements. The scope of this position impacts cancer research efforts in Gastrointestinal Medical Oncology and throughout the institution.
Independently perform in vivo and in vitro studies for the validation and characterization of targets or therapeutic agents in the area of oncology and tumor immunology.
Independently perform in vivo model development, target inhibition, efficacy, mechanism of action, and PK/PD studies, and will evaluate the influence of dose, schedule, and therapeutic combinations in various cancer models.
Plan and perform independent research projects using experimental assays techniques such as DNA, RNA, protein extraction, western blotting, Q-Real Time and digital PCR, IHC, ELISA and FACS.
Manage multiple in vivo experiments simultaneously. Plan and perform research project using molecular biology techniques, such as cloning, transfection, site-directed mutagenesis assay, allelic expression assay, siRNA and flow cytometry techniques.
Coordinate collection of clinical samples with clinical research personnel, including implantation and maintenance of patient-derived xenografts (PDX) along with drug treatment studies and co-clinical trials.
Maintain accurate data storage and record filling systems to include all pertinent data and specifications on all experiments performed. Use computer programs for data analysis and presentation. Review and analyze scientific data and laboratory test results.
Maintain a safe laboratory environment, including updating regulatory documents for animal use, chemical and laboratory safety.
Train and supervise new employees and visitors on laboratory safety and basic laboratory skills.
Submit purchase order requisitions and assist with inventory issues.
Provide analyzes of program operation and procedures to principal investigator when necessary.
Write and prepare experiment reports, preliminary data for grants, and manuscripts.
Supervise and assist with training of clinical and basic science fellows and graduate students.
Required: PhD in one of the natural sciences or related field or Medical degree.
Preferred: PhD in Biological Science.
Required: Five years of experience in experimental or scientific work.
Preferred: Eight years of relevant postdoctoral research laboratory experience. At least three years of relevant experience in experimental oncology research. At least three years of experience in experimental therapeutics research (using PDX models).
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Requisition ID: 125962
Employment Status: Full-Time
Employee Status: Regular
FLSA: exempt and not eligible for overtime pay
Work Week: Days
Fund Type: Soft
Pivotal Position: Yes
Minimum Salary: US Dollar (USD) 87,000
Midpoint Salary: US Dollar (USD) 130,000
Maximum Salary : US Dollar (USD) 173,000