Sr Scientist/Principal Investigator, In Vivo Pharmacology

About Alterome:

Alterome Therapeutics, Inc. was formed in December 2021 and officially launched operations in January 2022. We are a precision oncology biotech developing alteration-specific therapeutics to address high-value and validated oncogenic drivers. The company is led by a team of experienced leaders with a history of developing marketed oncology small molecule drugs. Alterome recently secured $132 million in Series B funding.

Job Summary:

Alterome is seeking an experienced Sr Scientist/Principal Investigator to drive in vivo studies for therapeutic proof-of-principle and translational studies in oncology programs. We are looking for an individual who enjoys working with animal models and brings scientific rigor, intellectual curiosity, collaborative enthusiasm, and a desire to innovate. We utilize CROs to advance our scientific mission and are looking for a colleague with strong communication skills to make contributions in-office and virtually. This individual will have the opportunity to work in a fast-paced and dynamic environment at the intersection of multiple teams to meet regulatory and clinical timelines.

Key Responsibilities:

• Initiate and manage in vivo experiments at external CROs to meet scientific goals

• Participate in planning, design, execution, and analysis of in vivo pharmacology experiments to assess compound efficacy, safety, and PK/PD profiles

• Oversee quality control, organization, and processing of data into company databases

• Prepare findings for frequent internal updates and regulatory documentation

• Manage & expand CRO relationships and identify new PDX or CDX models to advance scientific programs

• Summarize and report findings to team members and management

• Communicate scientific and technical perspectives to advance pre-clinical and translational studies

• Effectively communicate experimental findings in oral and written formats

• Work independently and collaboratively in a multidisciplinary team environment

Qualifications:

• BS, MS, or PhD in Pharmacology/Cancer Biology or a related discipline with 8+ (BS), 6+ (MS), or 3+ (PhD) years of relevant research experience

• Hands-on experience with design and execution of complex in vivo experiments utilizing CDX/PDX tumor models

• Demonstrated excellence and productivity in managing and organizing research studies

• Strong written and verbal communication skills

• A collaborative and accountable work ethic engaged with peers and management

• Detail-oriented with excellent organizational and record-keeping skills

• Experience in the pharmaceutical or biotechnology industry

• Strong experience collaborating and troubleshooting with CROs

• Builds strong relationships with peers, cross-functional team members, and CROs

• Extensive knowledge of cell line- and patient-derived xenograft models, humanized models, and genetically engineered mouse models in the small molecule discovery setting

• Solution-oriented and participates in a learning environment focused on scientific and professional growth

Who are Alterome Employees?

Although we share varied backgrounds and come with expertise in different areas, we aim to inspire hope for those affected by cancer. Our vision unites us to develop unique therapies that transform the lives of cancer patients, one alteration at a time. Thus, we seek the best people to join this special movement and invest the resources they need to grow, develop, and accomplish our collective goals. We have a passion for what we do and truly enjoy working with each other. In fact, many of us have worked together in multiple companies and there is a genuine camaraderie amongst the group. We would love to bring new faces to the group, and that's where you come in!

Alterome Offers:

We provide our employees with medical, dental, and vision coverage, life insurance, a 401k w/company matching, competitive compensation (including equity), paid holidays, flexible time off, home office set up, full-service gym on-site (with showers and towel service!), professional development opportunities, phenomenal company culture, and more! Our office is centrally located in San Diego, CA at the intersection of the 15 and 56 Freeways. This is a hybrid role with three days per week in the office required - out of state candidates will not be considered at this time.

Salary Information: $140,000-$185,000/year based on skills and experience.

EEOC Statement:

Alterome Therapeutics, Inc. is an equal opportunity employer committed to building a diverse and inclusive organization. We measure each applicant, candidate, and employee based on their qualifications for the role, regardless of age, sex, religion, sexual orientation, gender identity, national origin, Veteran status, disability, and/or any other protected class characteristics. Furthermore, Alterome is committed to achieving all business objectives in compliance with all federal, state, and local laws.