Sr. Scientist, Discovery Dmpk

The Position

Arrowhead Pharmaceuticals is seeking a Scientist to join our discovery DMPK group in the Chemistry Department. The successful candidate will play a critical role in understanding the ADME of Arrowhead's TRIM platforms targeting new cell types.

Responsibilities:

• Draft ADME study requests
• Perform cell type separation, enrichment and depletion as needed
• Perform LC-HRMS, LC-UV or qPCR based quantitation
• Interpret ADME results to facilitate drug delivery
• Act as discovery DMPK lead and present data in cross-functional meetings
• Document experimental procedure and results accurately
• Execute all assays in a timely manner to meet deadlines
• Be able to work in a highly dynamic and fast-moving environment; meet project goal within deadline

Requirements:

• PhD in pharmacology or biological sciences
• Hands-on experience with one of the quantitation method listed above from biological matrices
• Hands-on experience with cell separation, enrichment or depletion
• Demonstrated innovation, creativity and resilience in problem solving
• Excellent oral and written communication skills and collaborative personality
• Highly self-motivated with a can-do attitude

Preferred:

• Extensive experience in cell separation, enrichment and depletion
• Demonstrated practical understanding of pharmacokinetics and pharmacodynamics