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Sr. Research

Expired Job

Medfocus San Diego , CA 92101

Posted 2 months ago


The molecular mechanism group in the Protein Homeostasis TCoE is seeking a Senior Research Associate (one-year contractor) to assist the development of novel drugs that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these drugs will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities will include, but are not limited to, the following:

  • Identify and validate novel drug targets using cell-based assays

  • Utilize RNAi and CRISPR to determine the disease relevance of novel drug targets

  • Perform cellular experiments to help define the SAR of drugs

  • Utilize genetic and pharmacological approaches to define the MOA of candidate drugs

  • Design and develop novel assays

  • Document, interpret and troubleshoot results

  • Convey data analysis and interpretation to supervisor and colleagues

  • Communicate with peers and supervisors and foster teamwork

  • Contribute to collaborative efforts

  • Strong commitment to quality and reproducibility

  • Demonstrate adaptability

Skills/Knowledge Required:

  • DO NOT SUBMIT PhD candidates

  • Extensive wet-lab experience with routine molecular, cellular and genetic biology tools

  • Extensive experience with Cas9-CRISPR mediated gene editing and RNAi

  • Highly motivated and strong team player with a high degree of independence

  • Innovative and critical thinking

  • Excellent time management and organizational skills

  • Strong communication skills, both written and oral

Please send resume to

  • Min Salary:* $0.00

Max Salary: $0.00

City: San Diego

  • State:* CA
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Sr. Research

Expired Job