Sr. Research Associate / Associate Scientist, In Vivo Pharmacology

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum's two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies. The company's proprietary product engine identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.

Description

Fulcrum Therapeutics is seeking a Senior Research Associate/Associate Scientist, who will be a driven professional, eager to bolster our in vivo pharmacology research initiatives. This role involves spearheading the design and implementation of both in vivo and ex-vivo pharmacology studies, critically contributing to our understanding of the pharmacokinetics/pharmacodynamics (PK/PD), target engagement, and therapeutic efficacy of our novel drug candidates. As a crucial member of our multidisciplinary team, you will have the opportunity to lead and execute pre-clinical discovery studies, generating decisional data packages to support the advancement of clinical candidates.

Responsibilities

• Carry out rodent in vivo studies adhering to IACUC standards, independently and within a team dynamic.

• Design and execute studies ranging from early exploration to IND submission stages, focusing on in vivo/ex vivo sample generation and analysis, PK/PD modeling and therapeutic efficacy.

• Performing assays to assess target engagement and biomarker analysis in samples such as blood, bone marrow, and muscle tissue, contributing to our understanding of disease mechanisms.

• Develop, optimize and conduct in vitro assays and molecular biology techniques including but not limited to RT-qPCR, ELISA, protein assay and flow cytometry.

• Demonstrate independent thought/creativity in science with excellent collaboration and communication across functional disciplines and multitasking skills.

• Maintain accurate, timely and complete electronic laboratory notebook entries.

Qualifications

• BS or MS with relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an academic or industry setting.

• Experience working with rodents, administering doses through various methods including but not limited to PO, IP, IV, SC and IM, and conducting post-study processes including blood draws, necropsies, and ex vivo sample analysis.

• Experience with Contract Research Organizations (CROs) is an asset.

• Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, RT-qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.

• Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.

• Proven ability to independently plan and execute experiments, analyze data, and present findings.

• A passion for contributing to a team-oriented, diverse, and inclusive work environment.

• Excellent multitasking abilities and ability to thrive in a fast-paced, collaborative setting.