Sr. Antibody Technology Core Specialist

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

The Antibody Technology Sr. Specialist is responsible for supporting and collaboratively enhancing the antibody development needs of researchers at Fred Hutch. The Antibody Technology Sr. Specialist -Antibody Discovery and Production position will increase the antibody technology core's expertise in large scale protein production, and large-scale protein purification. This role must also have a willingness to learn all parts of the antibody discovery process and participate in the active development of new services and research opportunities.

At Fred Hutchinson Cancer Center, all employees are expected to demonstrate a commitment to our values of collaboration, compassion, determination, excellence, innovation, integrity, and respect.

Responsibilities

PRIMARY/ESSENTIAL DUTIES:

• Research Support: This varied role primary focus will be antibody production, antibody purification and size exclusion chromatography but are also likely to include generation of immunogens and screening reagents, including the recombinant protein and stable cell lines needed to discover antibodies. It will also include hybridoma generation, screening, and general hybridoma handling. It will include use of robotics and potentially some molecular biology.

• Research development: This position is expected to provide a high level of support for users of the antibody technology core by establishing and maintaining a positive and collaborative working relationships with faculty and external users. The candidate will develop advanced protocols or creative solutions for and deliver high quality products from the antibody discovery process. This person is expected to lead in the development of tools for antibody production and purification in the core.

• Equipment Oversight: This position is expected to be, or through training, become an expert on equipment in the antibody core such as Molecular Devices ClonePixII colony picker, IntelliCyt iQue Screener flow cytometer, AKTA Pure, Carterra SPR instrument and robotics automation used in the antibody discovery process. This role also serves as a resource for optimization of lab performance and efficiency. This candidate is expected to perform advanced equipment operation and maintenance or coordinate and complete maintenance on all equipment and software. This role participates in the review and identification of new equipment needs.

• Training and Education: The candidate will lead initiatives to develop new training materials, SOPs, and guidelines for optimizing investigator interactions with the antibody core. This person will be expected to present on new or expanded technologies within the antibody core. The role will also mentor junior staff within the Shared Resource.

• Administrative tasks: Tasks include completing batch records, updating liquid nitrogen logs and maintaining sample records. It will include communicating with the researchers who use the core as well as fostering positive relationships with vendors and service engineers who support the antibody core. Assistance with billing for service as required. As appropriate role will assist with Institutional Animal Care and use Committee protocol preparation.

Qualifications

MINIMUM QUALIFICATIONS:

• Protien scienced related Master's Degree and 10+ years of experience with large scale protein production and purification.
• OR-
• Protein science related Bachelor's Degree and 15+ years of experience with large scale protein production and purification.

PREFERRED QUALIFICATIONS:

• Demonstrated ability to learn and adapt to new systems and techniques.

• A background in Large scale HPLC including, protein A and G, size exclusion chromatography and ion exchange chromatography including column packing.

• Capability in performing antibody production at large scale in multiple formats with hybridoma, transient recombinant and stable recombinant being examples.

• Capability in performing antibody sequencing.

• Excellent communication, interpersonal and organizational skills.

• Ability to work in a collaborative team-oriented, core-lab environment.

• Experience with MS Office suite of applications (Outlook, Word, Excel, Sharepoint, Teams, One Drive, etc;)

• Record keeping and database management.

• Capable of undertaking work with minimal supervision and ability to manage multiple projects simultaneously.

• Can perform detailed research and review of technology through literature searches, outreach to experts in field and other informational sources.

• Basic rodent handling and procedural skills including animal immunization and familiarity with IACUC protocol management.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

The annual base salary range for this position is from $94,702 to $149,656 and pay offered will be based on experience and qualifications. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at hrops@fredhutch.org or by calling 206-667-4700.