Senior Vice President, Technical Operations

insitro is changing the way that drugs are discovered and developed for patients by addressing bottlenecks throughout the drug discovery and development value chain via predictive models derived from a combination of external human cohort data and high-quality molecular data generated in-house. To enable and implement this vision, we're building a unique, high-efficiency research and pre-clinical engine that incorporates a range of modern technologies - both experimental and computational - and deploys them robustly and at scale to generate a pipeline of differentiated therapeutics..

In this executive-level role, reporting to the CSO, you will work with the CEO, the Executive Team, and colleagues across the company to build an industrialized cell biology platform that creates biology insight generation, validation and therapeutic assessment using advanced machine learning and automation. You will also construct the preclinical infrastructure (Safety Assessment, CMC, supply chain, QA/QC) internally and with partners to translate these laboratory-generated Insights (combined with those from Clinical Machine Learning) into high-quality clinical candidates, and support their subsequent Clinical Development. Also, you will manage and extend a state-of-the-art core laboratory providing Omics and Materials Management capabilities to the scientific teams. Also, you will play a role in the implementation and maturation of R&D organizational structures that facilitate smooth goal setting, governance and execution in a matrixed organization. Finally, you will participate in the operation and evolution of the company and management of an emerging portfolio of diverse partnered and wholly owned therapeutics.

Your specific responsibilities will include the following:

• Oversee the development and deployment of productionized laboratory workflows and processes along the R&D value chain that contribute to pipeline advancement (target identification and credentialing to therapeutics discovery).

• Manage a Research Operations team that includes core functions, Materials Management and Omics capabilities

• Build Safety Assessment, CMC, supply chain and QA/QC capabilities (internally and externally) that will support the rapid transition of insitro to a multi-modality clinical stage company

• Establish processes for data and meta-data collection that support our research workflows while also enabling future regulatory filings.

• Oversee our lab and facilities operations, including oversight of existing space and future build.

• Ensure that R&D efforts are aligned with our goals and with fulfilling business deliverables to partners, even in the face of scientific uncertainty.

You will join an exciting biotech startup that has long-term stability due to significant funding, while maintaining a culture of innovation. You will work with a very accomplished team, learn a broad range of skills, and help shape insitro's culture, strategic direction, and impact on patient outcomes. Join us, and help make a difference!

About You

• PhD in biology, chemistry, bioengineering, or equivalent experience

• 15+ years of practical work experience in the biopharma industry

• Established operations leader with demonstrated accomplishment in complex organizations that span from discovery through scalable execution

• A documented history of success in the rapid development and introduction of complex technology products, which are integrated at the systems level

• An organizational builder and manager with the ability to understand the big picture and translate it into detailed, operational execution

• Experience in overseeing production-scale technology platforms relevant to the pharma R&D pipeline

• Considerable familiarity with high throughput biological or chemical lab environments involving extensive data collection

• Approaches decisions with data-driven rigor, in a way that integrates information from multiple partners

• Record of execution in work environments that are dynamic, and characterized by expansion

• Works with colleagues across a range of disciplines and to create agreement across diverse partners

• Enthusiasm for bold, goals and a passion for helping transform the lives of patients

Nice to Have

• Demonstrated affinity to the use of computational methods to accelerate drug discovery; exposure to AI/ML methods a considerable plus

• Understanding of the value of human genetics and human-derived models in drug discovery

• Broad knowledge of technology platforms that are relevant to drug discovery and development

• Experience working under the resource and time constraints of an early stage startup

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $315,000-$370,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions

• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), and mental health and well-being support

• Open, flexible vacation policy

• Paid parental leave

• Quarterly budget for books and online courses for self-development

• Support to occasionally attend professional conferences that are meaningful to your career growth

• New hire stipend for home office setup

• Monthly cell phone & internet stipend

• Access to free onsite baristas and cafe with daily lunch and breakfast

• Access to free onsite fitness center

• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We bring together diverse teams-grounded in multiple expertise and life experiences-and work even harder to ensure those teams succeed in inclusive, growth-oriented environments supported by equitable company and team practices. You can expect equitable treatment, respect, and fairness throughout the interview process.

About insitro

insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro's approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com.