Senior Small-Scale Fermentation Scientist - Assay Development

Ginkgo Bioworks Boston , MA 02298

Posted 2 months ago

Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world to answer the globe's growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms. Today, our world-class foundry is developing over 40 different organisms to make different products across multiple industries.

Core to our organism engineering pipeline is the testing and analysis of our engineered strains. We leverage high-throughput screens and selections to measure thousands of strains at a time for improved enzyme activity of key steps or increased titers of final products. Given the diversity of projects at Ginkgo, our assay development approaches must work across multiple hosts and products. Your novel screening and selection methods will lie at the center of our new high-throughput screening pipelines.

As a Senior Small-Scale Fermentation Scientist, you will utilize your extensive expertise in fermentation and organism physiology to guide the Small-scale Predictive Fermentation (SPF) team in the design of microtiter plate fermentation processes that are predictive of how strains will perform at larger scales. These processes will be used to screen large libraries (from hundreds to tens of thousands) of strains with robotic work cells and liquid handling workstations in the Foundry. You will consider how the plate fermentation processes integrate into downstream assays (including colorimetric, LC-MS, or GC-MS). The SPF team currently supports a wide range of projects with different organisms, product types, and large-scale fermentation processes, and your role will leverage your expertise across all of these projects. You will also have the opportunity to mentor and train other members of the SPF team.

Responsibilities

  • Guide the development and optimization of microtiter plate microbial fermentation processes based on larger-scale fermentation processes

  • Leverage your skills to help the team become more proficient in their understanding of fermentation processes across scale

  • Identify and onboard new methods and technologies to improve the team's capabilities

  • Execute high-throughput screens using the plate models that you and the team develop, and analyze your results to determine which strains would perform best in larger-scale fermentations

  • Aid in tech transfer of strains and processes to and from customers

  • Adapt readily to changing project needs and develop sophisticated problem-identification and problem-solving skills

Desired Experience and Capabilities

  • PhD or MS in biology, biochemistry, bioengineering, chemistry, chemical engineering, or related field

  • Five to ten years of industrial fermentation experience at multiple scales (plate, flask, bench, pilot, production)

  • Deep understanding of microbial metabolism and physiology

  • Familiarity with a wide range of industrially-relevant microbes (including bacteria, yeast and filamentous fungi) and mammalian cell lines

  • Excitement to learn how to work with new organisms

  • Familiarity with software and statistical platforms for the analysis of large data sets (e.g., JMP, Tableau, Spotfire, or MODDE pro/DoE)

  • Experience in computational analysis of biological data and large data sets using a general-purpose programming language (such as Python, R, or Matlab) is highly desirable, but not required

  • Desire to work in a collaborative, team-oriented environment

To learn more about Ginkgo, check out some recent press:

Ginkgo Bioworks CEO on scaling up Covid-19 testing: 'If we try, we can win' (CNBC)

Ginkgo raises $70 million to ramp up COVID-19 testing for employers, universities (Boston Globe)

Ginkgo Bioworks Redirects Its Biotech Platform to Coronavirus (Wall Street Journal)

Ginkgo Bioworks Provides Support on Process Optimization to Moderna for COVID-19 Response (PRNewswire)

The Life Factory: Synthetic Organisms From This $1.4 Billion Startup Will Revolutionize Manufacturing (Forbes)

Synthetic Bio Pioneer Ginkgo Raises $290 Million in New Funding (Bloomberg)

Ginkgo Bioworks raises $350 million fund for biotech spinouts (Reuters)

Can This Company Convince You to Love GMOs? (The Atlantic)

We also feel that it's important to point out the obvious here - there's a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equality, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.

We're developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can - and will - impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it's something we'll be proud of as it continues to grow. Therefore, it's critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
CMC Senior Scientist / Scientist Analytical Development Cell Therapies

Takeda Pharmaceutical Company Ltd

Posted 2 days ago

VIEW JOBS 2/24/2021 12:00:00 AM 2021-05-25T00:00 By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description The Analytical Development - Cell Therapies group is looking for a highly motivated colleague to support assay development activities, routine testing and characterization activities in support of our cell-based therapy programs. The ideal candidate will have a cell biology or immunology background and be able to apply that knowledge in the development and performance of various cell biology techniques to support programs going into clinical trials. The candidate should have indepth knowledge of flow cytometry techniques and their development and validation. Extensive knowledge of cell-based assay techniques is highly desirable and ability determine the appropriate type of assay to apply depending on the situation is needed. Additionally, this position participates in planning unit operations/experiments for direct and non-direct-reports which requires good collaboration and communication skills. Attention to detail, organization and knowledge of good laboratory documentation practices are desired. In support of our fast-paced department, the ideal candidate will be adept at managing multiple projects, people and studies simultaneously, while still producing consistent and reliable results. Experience with a variety of biological assays, including flow-cytometry, cell-based assays and/or other assays used to evaluate cell-based therapies and immune system cell types. The emphasis will be on flow-based assays. Experience with flow staining, multicolor flow cytometry and flow-based analytic platforms (such as FlowJo) is a plus. Adept overseeing multiple activities and managing the activities of reports. Able to conduct troubleshooting of multiple methods. Able to design experimental outlines, method development, validation, and transfer of method activities to internal and external laboratories. Able to support evaluation of new equipment/methodologies. Works extremely well with departmental and/or cross functional peers to execute on project plans. Accountabilities: * Develops and leverages strategic understanding of project and CMC priorities to plan/coordinate with cross-functional peers and evaluate impact of decisions across CMCC and other development functions * Contributes significantly to complex/multiple projects or functional areas through leading or influencing others * Influences and supports initiatives related to driving scientific and technical improvement within function and potentially cross-functionally * Reviews, interprets and communicates data cross functionally within CMC and project teams * Coordinates others in creating technical reports including reviewing and editing * Conducts analysis of technical and conceptual risk and trends * Identifies process trends and defines/champions process strategy or use of novel technologies * Recognized as a technical expert and resource within function * Significant technical responsibility for a project area/technical program within the department and potentially across CMCC (i.e. GCT lead). * Represents functional area on GCT project teams by communicating activities from designated functional area to project team * Identifies topics for initiatives and leads local/global initiatives as directed by senior staff. * Ensures a productive and development-rich environment; provides training/mentoring for junior staff. * Defines more complex/novel approaches and methodologies to solving complex technical challenges * Proactively identifies vendors and builds relationships to gain access to technologies as needed to deliver on pipeline goals. * Manages key vendor relationships across multiple projects as appropriate, and proactively affects resolution of issues arising at vendors. * Initiate and influence project direction outside department. Education and Experience: For Sr. Scientist: * Associates degree in biology, cell biology, biochemistry or related pharmaceutical science and 2+ years relevant industry experience * Bachelors degree in biology, cell biology, biochemistry or related pharmaceutical science; some relevant industry experience preferred * Appropriate laboratory training For Scientist: * Associates degree in biology, cell biology, biochemistry or related pharmaceutical science and 4+ years relevant industry experience * Bachelors degree in biology, cell biology, biochemistry or related pharmaceutical science; 2+ years relevant industry experience * Masters degree in biology, cell biology, biochemistry or related pharmaceutical science; 0+ years relevant industry experience * Previous experience working in lab setting or Masters degree plus appropriate laboratory training Knowledge and Skills: * Analytical and Problem Solving Skills -Able to troubleshoot critical issues or problems and resolve routine issues using appropriate information. * Teamwork -- Ability to work within department groups/team. * Communication Skills - Expresses one's self clearly and concisely within function; documents issues and/or concerns concisely with colleagues; timely and effectively communicates issues to supervisor * Organization - Exercises good time management skills * Technical - Proficient in use of applicable lab equipment and operations #LI-KD1 Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Takeda Pharmaceutical Company Ltd Boston MA

Senior Small-Scale Fermentation Scientist - Assay Development

Ginkgo Bioworks