Aviceda Therapeutics Cambridge , MA 02138
Posted 3 weeks ago
Job Description:
We are seeking a highly experienced Senior Scientist/Associate Principal Scientist - Formulation and Analytical Method Development to be a part of our rapidly growing talented research and development teams. This person will help advance our drug development platform with a strong background in nanoparticle drug delivery systems.
Responsibilities:(including, but not limited to):
Responsible for conceiving and delivering nanoparticle formulations to support early discovery and preclinical studies.
Conduct experiments, independently and in collaboration with colleagues in support of project goals.
Characterize polymers, drug substance and nanoparticles using advanced analytical and characterization techniques (HPLC, DLS, NMR, etc.)
Perform formulation characterization using techniques such as pH, osmolality, particle sizing, and zeta potential
Identifying potential stability and performance issues with prototype formulation
Develop cutting-edge conjugation chemistries to further advance Aviceda's proprietary glyco-immunology platform.
Collaborate and integrate with chemistry/biology workflow to develop and screen nanoparticles with desired properties.
Develop/sustain relationships with CROs to conduct animal studies and be the point person for material supply.
Additional responsibilities include formulation/analytical support for CMC activities such as drug product manufacturing, evaluating batch records and regulatory filings.
Maintain general laboratory functionality, including lab equipment maintenance and lab supplies.
Drive Aviceda's innovation with novel ideas and detailed documentation
Requirements:
Minimum of M.S. with 3 to 5+ years or Ph.D. with 2 to 5 years of related experience in the biotech industry. Degree in Pharmaceutical sciences, Materials Science, Polymer Chemistry, Chemical Engineering, Chemistry, or a related field.
Background in nanoparticle formulation development strongly desired. Specific background in polymeric nanoparticles is a strong plus.
Prior experience working on sterile dosage form would be a plus.
Hands-on experience in development of processes such as micro-fluidization, evaporation, TFF and sterile filtration.
Prior experience on HPLC method development will be plus.
Strong communication, organizational and interpersonal skills are necessary for this role
Demonstrated record of working successfully with cross-functional teams including early research and development and CMC teams.
Ability to work in a fast-paced environment with a sense of urgency and handle multiple roles.
Work in close collaboration within the research team to ensure successful completion of projects. Ability to plan and manage complex activities and prioritize tasks to deliver on
Education:
Aviceda Therapeutics