We seek an accomplished Senior Scientist level oncologist to join the Translational Sciences group within the Oncology Research & Development (ORD), La Jolla, California. The successful candidate will join a dynamic team of scientists in the Oncology Translational Sciences Group, playing a lead role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.
The Senior Scientist will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to signal transduction, targeted therapeutics, and epigenetics. The candidate will characterize and develop large and small molecules in close collaboration with partner lines as an integral member of the drug discovery teams. The ideal applicant will employ and develop cutting edge in vivo mouse and human cancer models. The individual will provide technical and scientific expertise in in vivo Pharmacology across ORD to enable target identification, validation, prioritization, and efficient drug discovery. Ideal applicants will be collaborative and team-oriented, possess excellent communication, leadership and organizational skills and a commitment to excellence.
Work within multi-functional teams to support large and small molecule drug discovery and combination therapy.
Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Interpretation, presentation and documentation of experiments within an electronic lab notebook, as well as preparation of reports.
Written and verbal presentation of results within a multidisciplinary team environment.
Develop and characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel therapies.
Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings
Ph.D. in Cancer Biology, Immunology or equivalent experience in a related discipline (or B.S. degree with 9+ years' or M.S. degree with 7+ years' relevant industry experience).
Expertise in in vivo pharmacology and experience with animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry is desired.
Expertise with GEMM and humanized models highly desirable.
Hands on in vivo (e.g.: IV, PO dosing, blood/tissue collection, tumor implantation) and ex vivo skills (flow cytometry, western blot, ELISA).
Proven ability to make important contributions to cancer biology, immuno-oncology, or related fields.
Current knowledge of oncology research, drug discovery and development, with emphasis on drug resistance.
Ability to follow novel scientific or technological developments, and to implement them in the laboratory.
Excellent written and oral communication and presentation skills in English. Proficiency in all common office and scientific software.
Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.
Specific expertise in the study of cell cycle related Cyclin Dependent Kinases including direct assessments of cellular activity, localization and interaction with their molecular networks.
Non-Standard Work Schedule
Other Job Details
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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Research and Development