Senior Scientist, Translational

Overview

The Senior Scientist will perform experiments to identify biomarkers and mechanisms of action for tumor-infiltrating lymphocyte (TIL) therapy. Methods may include identification and functional assessment of tumor-reactive T cells, gene expression studies on TIL and tumor biopsies, multiplex immunoassays of tumor biopsies, and characterization of TIL and post-treatment PBMC by flow cytometry, NGS, or other methods.

This is an on-site position, located in Tampa Fl.

Essential Functions and Responsibilities

• Lead and supervise one or more research projects to identify correlates of TIL clinical activity or patient enrichment strategies.

• Design and execute research experiments involving a variety of protocols and techniques.

• Analyze and interpret experimental results. Make detailed observations and record them in a timely and relevant fashion.

• Work with bioinformatic experts to identify immune correlates of TIL clinical activity.

• Provide oversight and training to teammates.

• Investigate and develop new methods and technologies necessary for project advancement.

• Manage interactions with contract research organizations providing bioassay services.

• Act as the Translational representative on clinical study management teams.

• Present experimental results in written documents and oral presentations in internal and external meetings

• Maintain a high level of professional expertise through regular scientific literature surveys and attendance of training and/or scientific seminars.

• Contribute to Regulatory documents and scientific publications.

• Must adhere to Iovance Biotherapeutics' core values, policies, procedures, and business ethics.

• Comply with Safety SOPs, SDS sheets, and laboratory procedures per company policy and OSHA regulations.

• Perform miscellaneous duties as assigned.

Required Education, Skills, and Knowledge

• PhD in Immunology, Cellular Biology, or related discipline required.

• 8+ years of combined post-doctoral training and industry experience.

• Immuno-oncology or immune mechanisms experience.

• Demonstrated ability to develop and run complex experiments and project strategies independently.

• Utilizes critical thinking skills to analyze, interpret, and draw conclusions independently.

• Strong interpersonal skills, including effective verbal and written communication skills.

• Must be able to present complex data to diverse audiences in an effective manner.

Preferred Education, Skills, and Knowledge

• Industry experience preferred.

• Experience with in vitro T cell functional assays, flow cytometry staining, and acquisition techniques is a plus.

• Prior experience working with human T cells and PBMC is also a plus.

The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodations may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request an accommodation.

Physical Demands and Activities Required

• Must be able to move to and from the office to the lab located on separate floors and move about the office and lab as needed.

• Must be able to remain in a stationary position, standing or sitting for prolonged periods of time.

• Must be able to grasp with both hands, perform repetitious actions such as pinch with thumb and forefinger, turn with hand/ arm, and reach above shoulder height.

• Must be able to use several types of laboratory equipment and pipettes for extended periods.

• Must be able to work on a tablet or computer typing for 50% of a typical working day.

• Must be able to move and lift 20 pounds multiple times daily.

• Must be able to use near vision to view samples at close range.

• Wear proper personal protective equipment, such as safety glasses, lab coats, and closed-toed shoes, when in a laboratory setting.

Mental: Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines

Work Environment

This position will work in both an office and a laboratory setting. When in the lab, there may be a risk of exposure to hazardous or biological waste within the environment through receipt, transport, storage, preparation, dispensing, administration, cleaning, and/or disposal of contaminated areas and waste. Depending on experiments or project deadlines, working evenings, holidays, or weekends may occasionally be required.

The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or change the position's responsibilities at any time.

Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual's race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please get in touch with careers@iovance.com.

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