Senior Scientist, Quantitative Systems Pharmacology

The Position

Verve is seeking an experienced modeling senior scientist to join our team as we continue to advance gene editing medicines for cardiovascular disease into clinical development. The successful applicant will develop fit-for-purpose, quantitative systems pharmacology (QSP) models and support pharmacometric modeling across key gene editing programs. The modeler will collaborate closely with scientists across the non-clinical (in vivo pharmacology, bioanalysis, and toxicology) and clinical teams to provide feedback on interpretation of experimental data and on study design to advance the understanding of gene editing drugs. In addition, and in collaboration with expert consultants, they will analyze data obtained from trial participants treated with Verve gene editing products. The individual will help develop the overall strategy for quantitative systems pharmacology and support effective communication with health authorities.

Job Responsibilities

• Develop and apply QSP and pharmacokinetic models to programs for novel gene editor modalities and disease modeling platforms at Verve.

• Independently analyze, interpret, and report PK, PK/PD, and QSP modeling results for internal decision making and regulatory filings.

• Develop modeling and simulation strategies for interpretation and design of preclinical studies, and mechanistic projection of pharmacodynamic data in varied patient populations.

• Support the clinical pharmacology, and clinical development groups at Verve to implement back-translation of early clinical exposure and pharmacodynamic data.

• Work closely with Verve pharmacologists, toxicologists, and bioanalytical team to help design in vivo studies and in vitro studies to characterize gene editing therapies.

• Maintain visibility of QSP and pharmacometrics functions internally and externally through publications, and presentations and mentoring non-modeler scientists.

• Other duties as assigned.

Qualifications

• Ph.D. (or equivalent) degree with a focus in quantitative systems pharmacology, mathematical modeling, or related disciplines.

• At least 5 years' relevant experience in the pharmaceutical/biotech industry, including at least 2 years of exposure to concepts of quantitative systems pharmacology and pharmacometrics.

• A thorough understanding of quantitative systems pharmacology, pharmacometrics principles including familiarity with pharmacology/safety aspects of drug discovery and development.

• Direct experience with modeling tools such as MATLAB/Simbiology, WinNonLin.

• Experience with coding using the R/Python or similar languages.

• Ability to collaborate and influence at all levels across an organization.

• Exceptional written and verbal communication allowing oneself to communicate scientific data and information to others in a digestible format.

• Analytical mindset and good problem-solving ability.

• Demonstrated ability to critically evaluate and contribute to multiple scientific programs.

• Diligence and attention to detail.

• Good organizational skills.

• Track record of regulatory interactions, including authoring of regulatory documents and responding to and resolving regulatory requests for information.

• Command of current literature in quantitative systems pharmacology with recent contributions including publications and conference presentations.

The targeted salary range for this position is $145,000 - $175,000 per year. Verve is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Verve's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.