Senior Scientist, Phage Display, Antibody Discovery

About the Role

We are seeking a Senior Scientist I that is highly motivated, flexible and an adaptive team player for the Antibody Discovery group within Biologics Research Center (BRC) Cambridge, MA. In this role, you will participate in the generation of high-quality biologics to initiate and competitively advance the NIBR biologics pipeline by independently performing antibody screening followed by binding and functional characterization.

This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Research Center (BRC) is accommodated within NIBR. BRC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

Your Key Responsibilities:

• Apply multiple innovative selection techniques to synthetic and immune antibody libraries, like phage display, yeast display, FACS sorting, plate-based screening.

• Use automation to support antibody production, purification, and screening

• Sub-clone hits into expression vectors and produce them at micro-scale in a high-throughput manner.

• Characterize binders properties in various affinity and activity assays, like ELISA, iQue, FACS, Octet, epitope binning, reporter gene assays.

• Engineer and improve binders by means of affinity maturation or humanization.

• Generate hypotheses to test, troubleshoot issues, design and execute the next set of experiments with the input from senior team members or manager.

• Document the results in a detailed manner in laboratory journal and in internal databases.

• Present research updates and participate constructively in working project teams and at laboratory group meetings.

Diversity & Inclusion / EEO

We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

• Novartis: e-mail [email protected] or call +1 (877)395-2339

• Sandoz: e-mail [email protected] or call: +1-609-422-4098

Role Requirements

Essential Requirements:

• B.S. with at least 6 years, or M.S. with at least 4 years in Biological Sciences with laboratory experience in antibody discovery technologies, including at least one technology like phage or yeast display.

• Solid background in molecular biology, cell biology, biochemistry, affinity and activity assays.

• Self-motivation, enthusiasm, and scientific curiosity.

Desirable Requirements:

• Experience in antibody engineering, especially affinity maturation is highly desirable.

• Knowledge in flow cytometry (analysis and sorting) is desirable.

• Familiarity with laboratory automation is desirable.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining

to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards: Read our handbook to learn about all the ways we'll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $92,800 - $139,200/year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

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suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?