Senior Scientist, Oligonucleotide Biology (In Vitro)-Rna, Gene Therapy & Delivery

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, Oligonucleotide Biology (In vitro)-RNA, Gene Therapy & Delivery located in La Jolla, CA.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/ .

RNA, Gene Therapy & Delivery is an organization within Therapeutics Discovery, committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with Janssen Therapeutic Areas (TA) discovery teams. Our mission requires critical thinking, a portfolio approach and deep scientific expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology and screening technologies coupled with an ability to work collaboratively with internal and external partners. This role offers tremendous growth opportunity within a dynamic and science driven organization.

Key Responsibilities:

• Lead from the bench to design and implement oligonucleotide therapeutic strategies, optimize efficacy, assess off-target and safety profiles, and select development candidates.

• Establish standardized and novel in vitro screening assays to identify efficacious oligonucleotide therapeutics and assess their safety and off-target profile for drug discovery programs.

• Serve as project co-lead for RNA therapeutics in collaboration with Therapeutic Area (TA) discovery leads to advance projects through the preclinical stage gates.

• Work collaboratively with partners in oligonucleotide chemistry, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions.

• Collaborate with colleagues in RNA, Gene Therapy & Delivery and Therapeutic Areas (TA) discovery teams to evaluate the function of lead oligonucleotide candidates in animal and cellular models of disease.

• Work with team members to implement screening campaigns for on-target efficacy and off-target profiling.

• Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports, and provide updates on project status.