Senior Scientist, Immunosuppression

Pfizer La Jolla , CA 92037

Posted 2 months ago


Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire a Senior Scientist for the Immunosuppression group.


  • Discovery and evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity

  • Design and execution of cell based functional and biochemical assays to select candidate molecules for clinical development

  • Perform multi color flow cytometry & RT-PCR

  • Processing of mouse TIL (tumor)

  • Communication of research results to team and company


  • Ph.D. with 1+ years of experience

  • Experience in the fields of immunology, cell biology and/or genetics

  • Ability to independently design, plan and execute and interpret experiments

  • Ability to manage an independent research program with minimal supervision

  • Expertise in standard immunologic techniques

  • Expertise in qRT-PCR, ELISA, MSD, ELISPOT, Nano string

  • Experience working with small molecules & antibodies (inhibitors/agonists) for tumor immunotherapy

  • Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry and other high dimensional approaches including CyTOF.


  • Technical expertise with human immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, tumor-stroma immune cell co-culture assays)

  • Expertise in in vitro functional assays especially with human primary cells is highly desirable (PBMC isolation, immune cell purification, T cell stimulation, MLR, M1/M2 polarization, etc.)

  • Proficient in high dimensional flow cytometry & RT-PCR

  • Expertise in mouse TIL processing & FACS analysis

  • Previous drug development experience in biotech/pharma setting is highly desired

  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic


  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

  • #LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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Senior Scientist, Immunosuppression