Senior Scientist I

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

Key Responsibilities

• Responsible for developing, optimizing & executing new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.

• Work within multi-disciplinary project teams & act as a lead analytical & biophysical resource to guide development & advance pipeline.

• Resolve key project challenges by effectively utilizing available analytical tools, information & technical expertise.

• Develop, optimize & execute new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.

• Strategically advance scientific expertise within the Analytics group by conceiving & executing novel scientific research & development efforts to address project challenges & provide novel insights.

• Demonstrate leadership by advising & sharing knowledge & expert opinions with peers & senior management.

• Contribute to research that leads to peer-reviewed publications, reports & external presentations.

• Employ experience in protein analytical & biophysical characterization to discern protein critical quality attributes (physiochemical properties, post-translational modifications) & better understand protein structure-function relationships.

• Work in cross-functional teams with scientists across functions & therapeutic areas (Virology, Immunology, Oncology & Neuroscience) to discover & develop next generation biologics through interrogation & engineering of protein attributes across both targets and therapeutic molecules.

• Responsible for utilizing verbal & written skills & the ability to clearly present scientific concepts & results for functional scientific & non-scientific leaders.

• Employ experience with in-depth protein analytical characterization using a variety of techniques such as LC-MS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF.

• Employ experience utilizing various software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, & ImageJ.

• Responsible for demonstrating proficiency with various chromatographic techniques, capillary electrophoresis methodologies & in-depth biophysical characterization.

• Responsible for preparation and characterization of disease-relevant proteins in defined morphological states. Employ experience in guiding recombinant protein expression & purification.

• Employ experience with protein labeling & conjugation, as well as protein formulation & remediation. Prepare written documentation, reports & presentations of work & strategies.

• Work on the selection of targets or variants for therapeutic development & include the design, engineering & characterization of resulting therapeutics & their mechanisms of action.

• Employ experience with routine mass spectrometry workflows, including intact & subunit analysis.

• Responsible for project driven initiatives that will require scientific exploration & experimentation as well as close collaboration with scientists across the organization.

• Responsible for new technology development by expanding analytical expertise & custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering & developing novel therapeutics.

Qualifications

Must possess a Bachelor's or foreign equivalent degree in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus 10 years of related progressive experience.

In the alternative, employer will accept a Master's degree or foreign equivalent in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus 8 years of related progressive experience, or employer will accept a Ph.D. degree or foreign equivalent in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus an academic or industrial background.

Must possess expertise/knowledge sufficient to adequately perform the duties of the job being offered. Expertise/knowledge may be gained through employment experience or education. Such expertise/knowledge cannot be "quantified" by "time". Required expertise/knowledge includes:

(i) developing, optimizing and executing new analytical methods and techniques to characterize complex proteins/glycoproteins, antigens and novel protein-based therapeutics;

(ii) in-depth protein analytical characterization using a variety of techniques including: LCMS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF;

(iii) software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, & ImageJ;

(iv) various chromatographic techniques, capillary electrophoresis methodologies and in-depth biophysical characterization;

(v) routine mass spectrometry workflows, including intact and subunit analysis; &

(vi) expanding analytical expertise and custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering & developing novel therapeutics.

Employer will accept any suitable combination of education, training or experience.