AbbVie Immunology is expandingits early discovery at Cambridge, Massachusetts. This new immunology researchgroup at AbbVie Cambridge Research Center (ACRC) will focus on identifying newtargets for the treatment of autoimmune and chronic inflammatory diseasesthrough computational analysis of human disease tissue derived datasets, andvalidating targets using in vitro andin vivo experimental approaches. Weare seeking a highly skilled and dedicated individual with immunologylaboratory experience and bioinformatics expertise to partner with a functionalgenomics group and with in vivopharmacologists to develop novel platforms for target selection and validation.This position requires passion, attention to detail, hands-on experience andteamwork.
Identification and validation of novel targets for thetreatment of inflammatory conditions.
Development of strategic plans to guide the selection andprioritization of identified targets.
Generate proof of concept data supporting target Go/No Godecisions using in vitro and in vivo platforms.
Conceptualize and execute novel approaches for targetdiscovery and contribute to new technology development and platform building.
Planning andcoordination of experiments with internal and external team members andfacility operations.
Analysis andpresentation of in vitro and in vivo study data, providing scientificinterpretations and recommendations in lab meetings and project team meetings.
Maintainingaccurate and well-organized records and laboratory notebooks.
Supportingdevelopment of protocols, study reports and data presentations.
BS, MS or PhD in Immunology/Biological Sciences or in a related discipline with 10+ (BS), 8+ (MS) or 0+ (PhD) hands-on experience working in a laboratory.
Expertise in the study of inflammatory diseases such IBD and/or other rheumatic disorders. Experience in human tissue processing is a plus.
Proficient in laboratory skills such as animal models, tissue handling for molecular and cellular phenotyping, multicolor flow cytometry and cell sorting, and gene and protein cellular and tissue expression.
Independent design, development and evaluation of well-controlled in vitro assays to address target biology and drug biology.
Experience in generating knockout, knockdown or enzymatically inactive target protein cell systems using approaches such as siRNA, shRNA and CRISPR for testing target validation hypotheses is desirable.
Excellent communication and organizational skills.
Must be a quick-learner and be a team-player.
Key AbbVie Competencies:
Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
Learns fast, grasps the "essence" and can change course quickly where indicated.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled