Senior Scientist I, Drug Metabolism

Pharmacyclics Sunnyvale , CA 94085

Posted 2 months ago

Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

General Position Summary/Purpose:

The DMPK department at Pharmacyclics, Sunnyvale, CA is seeking a motivated Scientist to join the ADME/DMPK group. The responsibilities include routine ADME in vitro assays and understanding the SAR for lead optimization. A strong background in delineating hepatic and extrahepatic biotransformation pathways and structural elucidation by LC-MS is required. Work closely with bioanalytical and PK scientists to integrate ADME data for drug discovery and development. Experience with in vivo preclinical and ADME assays and understanding of clearance route, mechanism and the role of metabolism is preferred.

Key Accountabilities/Core

Job Responsibilities:
  • Good understanding of organic/structural elucidation chemistry, xenobiotic and extra hepatic metabolism is required

  • Promote awareness of scientific and technical developments in the field of electrophilic covalent/reversible drugs, apply them to exploratory programs to facilitate the discovery of promising next generation drug targets

  • Enzyme substrate/ inhibitor kinetics for CYP and non CYP pathways required

  • Be proficient with cell culture technique. Primary hepatocyte cell culture experience is preferred.

  • Ability to execute laboratory techniques essential for in vitro ADME analysis (TDI, CYP inhibition, reaction phenotyping, permeability) for lead optimization in drug discovery

  • Proficiency in LC-MS method development for separation and structural identification of multiple metabolites from various matrices

  • Hands on experience in operation, maintenance & trouble shooting of LC-MS instruments of multiple vendors (Sciex/Thermo) and associated software's

  • Maintain accurate records and write in vitro ADME reports for in-house studies

Education, Qualifications, and Experience Requirements (degree, certifications, etc.):

  • PhD degree (1-5 years) B.S. or MS degree (5-10 years) equivalent in drug metabolism or related discipline with relevant industrial experience in drug discovery/development

  • Prior experience with HPLC and LC-MS are required. Familiarity with AB Sciex and/or Thermo Orbitrap high resolution mass spectrometry instruments are a must

  • Experience in utilizing radio-labeled material would be preferred

  • The candidate must be able to analyze data and maintain detailed, accurate and comprehensible study documentation. Experience with various scientific data base is a plus

  • The individual is also expected to be organized, a team player, enthusiastic about drug discovery, and possess effective communication skills

Equal Opportunity Employer Minorities/Women/Veterans/Disabled

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Senior Scientist I, Drug Metabolism