Senior Scientist

Hoffmann-La Roche Inc. Santa Clara , CA 95051

Posted 5 months ago

Internal Job Description

Sr. Scientist Template Production (RED, Bioproduction)

Roche Sequencing Solutions (RSS) is a fast moving, highly technical team of people with the ambitious goal of disrupting Next Generation DNA Sequencing. Our technology fuses active biological and solid-state elements to bring single molecule-based sequence detection to scale. Developing this unique platform requires expertise across a range of fields: Software Engineering, Data Science, Information Theory, Biophysics, Biology, Chemistry, Protein Engineering, Digital and Analog Circuit Design, and Electrochemistry, just to name a few.

We are looking for a highly motivated, passionate and team-oriented individual with laboratory experience in NGS library preparation and various sample preparation techniques. This individual will be working as part of our bioproduction team in research and early development (RED) supporting DNA template production for use on our nanopore sequencing technology. The individual must be highly detail oriented and meticulous. Experience in sample preparation, DNA purification, and NGS library preparation methods is required.

This individual will work as part of a small, but integral team, as well as collaborate cross-functional teams. They will report to the template production manager and work very closely with junior level scientists by providing technical oversight and mentoring. Individual will participate in aspects of project planning, and will work closely with manager to design experiments, identify opportunities for process improvements, and plan, design and execute studies to improve workflows. Utilizes DOE where appropriate, and is familiar with basic data analysis techniques. Maintains exceptional data records, and regularly deliver presentations internally of project data.

Responsibilities Include:

  • Designs, plans and conducts assigned research and/or development-related experiments/studies utilizing established and innovative procedures.

  • DNA template construction, QC and method validation.

  • Troubleshoots and resolves difficult problems in creative ways by taking a new perspective on existing solutions, exploring and implementing new concepts and methodologies.

  • Accurately and consistently records experimental methods, materials and results in electronic laboratory notebooks.

  • DNA extraction and purification methods

  • Characterizing DNA using UV/VIS spectroscopy, fluorescent based assays, and gel electrophoresis.

  • SPRI -Magnetic bead-based DNA purification

  • Preparation of genomic DNA libraries as well as novel, synthetically constructed DNA templates.

  • Nanopore platform sequencing and data analysis

  • Maintaining production protocols, databases and batch records

  • Analyzes data, evaluates results, forms conclusions and implements/documents process improvements. Integrates previous and current results to determine next experimental steps. Presents findings at group or departmental meetings.

  • Works according to Roche's commitment to quality and adheres to Roche's core business principles.

Job Qualifications:

  • Ph.D. in biochemistry, chemistry, molecular biology or related discipline is preferred. M.S. or B.S with equivalent industrial experience.

  • Deep understanding of analytical approaches and tools for genomic data analysis plus familiarity with genome databases. Candidates with proven expertise in the analysis of NGS data

  • Demonstrated experience with DNA purification and analytical methods

  • Experience with enzymatic reactions and process development.

  • Demonstrated meticulous documentation capabilities

  • Demonstrated strong analytical skills with methodical approaches to trouble-shooting

  • Experience in writing and following Work Instructions, Batch Records and Standard Operating Procedures is a plus

  • Demonstrated critical thinking and meticulous attention to detail

  • Strong oral and written communication skills is a must

  • Agile/flexible with fast-paced work environment; ability to work both efficiently and independently.

  • Experience in the use of a high-level programming language such as R (preferred) or Python for computational data analysis preferred.

  • Must be able to lift 25 lbs.

Roche is an equal opportunity employer.

Research & Development, Research & Development > Research


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Data Scientist II

Akamai Technologies Inc

Posted 2 days ago

VIEW JOBS 12/12/2019 12:00:00 AM 2020-03-11T00:00 Overview If you have a deep passion for data and security, love handling massive data sets, and get excited from solving hard problems, Akamai is the place for you. We are seeking a highly motivated Senior Data Scientist who will work with team of scientists developing the next generation of Akamai's security algorithms, which are used to protect our global customer base from web attacks, automated bots and online fraud. Responsibilities include but are not limited to: * Analyze large volumes of data to develop and improve for malicious bot detection, behavioral authentication and fraud detection * Design scalable processes to collect, manipulate, present, and analyze large datasets in a production ready environment, using Akamai's big data platform * Develop working prototypes of algorithms (statistical and machine learning based) and evaluate and compare metrics based on the real-world data sets. * Lead projects in a technical capacity * Work closely with our engineers to deliver code across our platform * Contribute to security communities through papers, blogs, and presentations About the Team The Web Security Engineering team has responsibility for the technologies that power Security Products. These include Kona Site Defender, Bot Management, Web Application Firewall and Siteshield. These provide protection from both DDoS and application specific web attacks with high availability. Akamai's global footprint of over 220,000 servers provides an overlay network with scale and capacity to not just deliver the largest web events but also secure the largest Internet brands from attack. The team builds and extends Akamai's highly fault-tolerant wide area distributed content delivery and application acceleration systems to improve performance, security, reliability and availability of high value web sites. Akamai powers over 85% of the top online retailers, with over $2 billion in annual revenue. Required Education and Experience: * 8 years of relevant experience and a Bachelor's degree in Computer Science or Applied Math or Statistics or Machine Learning or its equivalent * 5 years' experience with statistics and experience with machine learning algorithms/techniques * 5 years' experience working with programming languages and big data environments, specifically, Python, Java, Spark and Hadoop * 3 years' experience with web technologies - HTTP, HTML, TLS/SSL and JavaScript * 3 years' experience in applying machine learning techniques to real-world data * 3 years' experience with Data Structures, Algorithms and Design Patterns Desired Qualifications: * Passion for solving challenging analytical problems * Ability to work productively with team members, identify and resolve tough issues in a collaborative manner * Previous research experience in Machine Learning specifically anomaly detection * Masters or higher degree in applied math, statistics, machine learning, computer science or relevant subject * Understanding of Web Application security, specifically topics such as SQL Injection, Cross-Site Scripting, CSRF and so forth * Fraud modelling experience Akamai Technologies is an Affirmative Action, Equal Opportunity Employer that values the strength that diversity brings to the workplace. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status. Akamai Technologies Inc Santa Clara CA

Senior Scientist

Hoffmann-La Roche Inc.