Senior Scientist Computational Geneticist

Amgen Inc. Cambridge , MA 02138

Posted 3 months ago

Career Category


Job Description

The Translational Systems Biology Group within the Comparative Biology and Safety Sciences (CBSS) department at Amgen Cambridge is committed to bringing safe and transformative medicines to patients. Our mission is to apply a variety of human-centric approaches including human genetics along with cell, molecular, computational and structural biology techniques to develop methodologies that can assess the safety of our drug targets or elucidate mechanisms leading to toxicity.

We are seeking a talented Senior Scientist to join our Translational Systems Biology Group in Amgen Cambridge. We are particularly interested in candidates with a strong background in human genetics, pharmacogenetics and functional genomics. The successful candidate will play a hands-on role using a variety of computational and statistical tools to investigate the safety of potential therapeutics or target interventions.

Key responsibilities

  • Drive in silico efforts focused on using human genetics and functional genomic datasets to elucidate the biology of targets we are pursuing in order to inform the safety profile of our drug targets

  • Perform large-scale analyses using multiple data types (e.g. pre-clinical data, drug side-effects, genetic variation, pharmacology) to support our predictive safety efforts

  • Lead the design, execution, and interpretation of genetic studies to investigate the influence of genetic variants on drug response

  • Define the overall strategy and goals for the application of human genetics/pharmacogenetics to drug safety assessment

  • Initiate, design and establish internal and external collaborations in the area of human genetics to inform target selection, safety assessment and de-risking

  • Mentor associates and postdoctoral fellows who lead genetic studies and projects, including wet lab molecular genetics experiments

  • Interface directly with bioinformaticians and computational biologists to develop experimental plans and interpret genetic association studies

  • Integrate other efforts within the group focused on human cell-based models and systems biology

  • Collaborate with researchers and clinicians within Amgen to interpret nonclinical and clinical data

  • Represent the Translational Systems Biology Group internally and externally through presentations, publications, networks, collaborations and conferences to promote the science of human genetics for safety assessment

Basic Qualifications:

Doctorate degree and 2 years of scientific experience


Master's degree and 4 years of scientific experience


Bachelor's degree and 6 years of scientific experience

Preferred Qualifications:

  • PhD in computational biology, biostatistics, bioinformatics or a related field with 5+ years of human genetics and functional genomics experience

  • Ability to design and lead human genetics studies (with a variety of study designs) delivering novel and actionable genetic findings relevant to drug development

  • Expertise with multiple molecular genetic approaches including chip-typing, WES & WGS, Sanger, targeted sequencing, etc. as well as other functional genomic technologies.

  • Familiarity with statistical genetics and deep knowledge of statistical modeling, supervised and unsupervised learning

  • Proficiency in computing languages such as R, Python, C/C++ and hands on experience in genetic and genomic data analysis

  • Expertise in molecular characterization and functional studies geared towards elucidating the mechanistic basis for genetic associations

  • Strong publication track record in top tier journals

  • Comfortable working in a highly interactive and vibrant environment designed to promote frequent interaction and brainstorming

  • Excellent leadership and communication skills and the ability to influence, inspire and lead the team into new scientific areas

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:

  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams

  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities

  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business

  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement

  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages

  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.


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