Senior Scientist Computational Geneticist

Amgen Inc. Cambridge , MA 02138

Posted 3 months ago

Career Category

Research

Job Description

The Translational Systems Biology Group within the Comparative Biology and Safety Sciences (CBSS) department at Amgen Cambridge is committed to bringing safe and transformative medicines to patients. Our mission is to apply a variety of human-centric approaches including human genetics along with cell, molecular, computational and structural biology techniques to develop methodologies that can assess the safety of our drug targets or elucidate mechanisms leading to toxicity.

We are seeking a talented Senior Scientist to join our Translational Systems Biology Group in Amgen Cambridge. We are particularly interested in candidates with a strong background in human genetics, pharmacogenetics and functional genomics. The successful candidate will play a hands-on role using a variety of computational and statistical tools to investigate the safety of potential therapeutics or target interventions.

Key responsibilities

  • Drive in silico efforts focused on using human genetics and functional genomic datasets to elucidate the biology of targets we are pursuing in order to inform the safety profile of our drug targets

  • Perform large-scale analyses using multiple data types (e.g. pre-clinical data, drug side-effects, genetic variation, pharmacology) to support our predictive safety efforts

  • Lead the design, execution, and interpretation of genetic studies to investigate the influence of genetic variants on drug response

  • Define the overall strategy and goals for the application of human genetics/pharmacogenetics to drug safety assessment

  • Initiate, design and establish internal and external collaborations in the area of human genetics to inform target selection, safety assessment and de-risking

  • Mentor associates and postdoctoral fellows who lead genetic studies and projects, including wet lab molecular genetics experiments

  • Interface directly with bioinformaticians and computational biologists to develop experimental plans and interpret genetic association studies

  • Integrate other efforts within the group focused on human cell-based models and systems biology

  • Collaborate with researchers and clinicians within Amgen to interpret nonclinical and clinical data

  • Represent the Translational Systems Biology Group internally and externally through presentations, publications, networks, collaborations and conferences to promote the science of human genetics for safety assessment

Basic Qualifications:

Doctorate degree and 2 years of scientific experience

OR

Master's degree and 4 years of scientific experience

OR

Bachelor's degree and 6 years of scientific experience

Preferred Qualifications:

  • PhD in computational biology, biostatistics, bioinformatics or a related field with 5+ years of human genetics and functional genomics experience

  • Ability to design and lead human genetics studies (with a variety of study designs) delivering novel and actionable genetic findings relevant to drug development

  • Expertise with multiple molecular genetic approaches including chip-typing, WES & WGS, Sanger, targeted sequencing, etc. as well as other functional genomic technologies.

  • Familiarity with statistical genetics and deep knowledge of statistical modeling, supervised and unsupervised learning

  • Proficiency in computing languages such as R, Python, C/C++ and hands on experience in genetic and genomic data analysis

  • Expertise in molecular characterization and functional studies geared towards elucidating the mechanistic basis for genetic associations

  • Strong publication track record in top tier journals

  • Comfortable working in a highly interactive and vibrant environment designed to promote frequent interaction and brainstorming

  • Excellent leadership and communication skills and the ability to influence, inspire and lead the team into new scientific areas

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:

  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams

  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities

  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business

  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement

  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages

  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

.


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Computational Biologist

Merck & Co., Inc.

Posted 3 days ago

VIEW JOBS 10/17/2019 12:00:00 AM 2020-01-15T00:00 Job Description Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough. We are seeking an innovative Masters or PhD level Computational Biologist to join our Company's Exploratory Science Center (ESC) in Cambridge, MA. * Become part of a creative and flexible team that will investigate sequencing-based microbial diagnostics, the influence of the microbiome on host immunity, and microbiome-immunology therapeutic development. This will be done with the ultimate goal of addressing significant unmet medical needs in infectious diseases, immuno-oncology, neuroscience, and broader indications. * Work with an interdisciplinary team of scientists to perform analyses of genetic and genomic data, with particular emphasis on data analysis of primarily microbial "omics" data (e.g. metagenomics, meta-transcriptomics, meta-proteomics, and microbial metabolomics). * Must have a proven track record using computational methods in at least one next generation sequencing modality. * Very strong collaboration, organization, and communication skills are required. * Must be passionate about science and excited to learn new things. * 10% Travel. Education Minimum Requirements * MS or PhD in computational biology, genomics, bioinformatics, biostatistics, or related field (e.g. molecular biology, microbiology) with strong computational component. Required Experience and Skills * MS 2+ years of relevant experience, or PhD with 0+ years of postdoctoral/industry experience * Programming experience (e.g. R and/or Python) * Unix/Linux OS experience and Bash scripting * Experience working in a high performance computing environment and managing data and workflows Preferred Experience and Skills * Research experience in any of the following areas: microbiome/microbiology, immunology, next generation sequencing data analysis, genomics, evolutionary biology, neuroscience, data science * Familiarity or experience with microbiome analysis tools (e.g. Mothur or Qiime) and genomics tools (e.g. Bowtie, BLAST) * Experience in sequencing-based diagnostics * Experience working with version control tools such as git (e.g. GitHub, BitBucket) * Familiarity or experience with relevant "bench" methods (e.g. PCR, sequencing library preparation, ELISA/ELISpot, FACS, microbial culturing) We are a research driven bio-pharmaceutical company. Our mission is built on the simple premise that if we "follow the science" and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are … Merck & Co., Inc., Kenilworth, New Jersey, USA is known as "Merck" in the United States, Canada & Puerto Rico. We are known as "MSD" in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products. We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world's biggest investors in Research & Development. What we look for … In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth. INVENT. IMPACT. INSPIRE. NOTICE FOR INTERNAL APPLICANTS In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions. If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor. If you need an accommodation for the application process please email us at staffingaadar@merck.com For more information about personal rights under Equal Employment Opportunity, visit: EEOC Poster EEOC GINA Supplement OFCCP EEO Supplement OFCCP Pay Transparency Rule We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic/International VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Shift: Valid Driving License: Hazardous Material(s): Number of Openings: 1 Merck & Co., Inc. Cambridge MA

Senior Scientist Computational Geneticist

Amgen Inc.