Senior Scientist, Chromatographic Separations, Early Oncology

Senior Scientist, Chromatographic Separations, Early Oncology

Join us at AstraZeneca as a Senior Scientist in our Early Oncology discovery chemistry team. This is an exciting opportunity to be part of a core analytical team that supports Oncology projects from target identification through lead optimization and pre-clinical delivery of candidate drugs.

You will be responsible for the reliable isolation of high purity chiral and achiral lead-like compounds with high recovery and quick turnaround times. This is a hands-on laboratory position based in Waltham, MA, with a planned relocation to Kendall Square, Cambridge, MA in 2026.

Accountabilities:

As a Senior Scientist, you will be tasked with analytical method development and purifications for chiral and achiral chromatographic separations using Reverse Phase and SFC. You will also handle post-purification dry down, QC, and registration. Additionally, you will support instrumentation, communicate cool science highlights, and tackle novel problems with innovative solutions across multiple instruments, softwares, projects, and workflows.

Essential Skills/Experience:

• PhD in analytical chemistry, chemistry, biotechnology, biochemistry, or equivalent with industry experience, or M.S. with 4+ years relevant industry experience, or bachelor's degree with 5+ years relevant industry experience.

• Proven experience with chiral and achiral separations of small molecules (~300-1500 MW) using HPLC-UV/MS and SFC-UV/MS at analytical and semi-prep or preparative scale.

• Expertise in analytical method development, validation, and problem solving.

• Strong written and oral communication skills.

• Strong time management skills, forward planning, and delivery focus.

• Steady performance demonstrating values and behaviors in interpersonal interactions.

• Experience with Waters and Agilent hardware, and MassLynx and ChemStation software.

At AstraZeneca, we are dedicated to pushing the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading Oncology enterprise united in our vision to eliminate cancer as a cause of death.

With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Ready to make a difference? Apply now to join us in our mission to eliminate cancer as a cause of death!

Date Posted

21-Jun-2024

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process.

We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.