This role is responsible for leading internal laboratory research projects on the biology of hypoxia-inducible factor (HIF) and renal research to advance the discovery and development of novel small molecules for clinical translation. You will intellectually and technically drive the identification of lead compounds by establishing and executing in vitro and in vivo models and determining mechanism of action. You will interact with cross-disciplinary functions within Research and Development and the broader organization. Moreover, you will lead identification and engagment with external partners such as contract research organizations and/or collaborators. You should be intellectually curious, a proven problem solver, and readily adaptable to changing scientific priorities. Excellent verbal and written communication skills are needed as is the ability to drive a project independently and as a member of a team. You will also provide supervision and scientific guidance to research associates.
Lead laboratory research projects in hypoxia biology to support drug discovery and compound characterization for pipeline development
Intellectually and technically lead internal research effort by developing, optimizing and executing cellular, biochemical, immunological, and molecular assays to meet project objectives.
Troubleshoot protocols, adapt new protocols and probe the scientific literature to identify new assays as needed.
Design and execute in vitro and in vivo pharmacology efficacy studies in disease models
Work closely with medicinal chemists in drug discovery setting to generate SAR and optimize drug properties and actions
Partner with Contract Research Organizations (CROs); interact directly with Principal Investigators and other key personnel for study coordination and planning, protocol development, research report review, and project timelines; monitor outsourced preclinical studies through regular communications and interim data reviews.
Analyze, interpret and effectively communicate research data.
Manage and direct others; oversee all aspects of laboratory management.
Write and publish major scientific findings.
Travel required for occasional conference, CRO study monitoring or collaboration.
Maintain accurate, up-to-date records in electronic laboratory notebooks, databases and/or spreadsheets for all experiments performed
PhD in Cell Biology, Molecular Biology, Immunology or related field. Completion of a post-doctoral fellowship is necessary. A minimum of 2-5 years biotechnology/biopharma or pharma industry is required.
Experience with small molecule drug development, advancing drug discovery programs and leading scientific research teams.
Experience in designing and establishing highly robust and validated bioassays.
Experience with mammalian cell culture, cell-based assays and biochemical/molecular techniques. Experience with immunology assays highly desirable.
Experience with outsourcing preclinical studies including CRO selection and management.
Excellent communication, multitasking, and collaboration skills
Strong publication record in peer-reviewed journals.
Background in hypoxia biology a plus and/or understanding of the biology of transcription factors.
Job Location Cambridge, Massachusetts, United StatesPosition TypeFull-Time/Regular
Akebia Therapeutics, Inc.