Senior Scientist (Proteomics Automation)

Senior Scientist (Proteomics Automation)

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing.

We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a part of our Dynamic Omics team in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC.

This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most powerful technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

Summary of the Group

Dynamic Omics is part of the Centre for Genomics Research (CGR) and Discovery Sciences within AstraZeneca, and works across all therapeutic areas (Oncology, Cardiovascular, Renal and Metabolism (CVRM), Respiratory and Immunology (R&I), Vaccines and Immunotherapies (V&I) and Neurosciences). You will be responsible for automating novel proteomic methods and procedures and improving the efficiency and throughput of our state-of-the art proteomics capabilities. The Dynamic Omics team delivers key data to projects across all phases of drug discovery and development, and we work with all modalities from small molecules to biologics. As a member of the Dynamic Omics and CGR groups, you will be actively involved in analyzing preclinical and clinical samples by implanting automated high-throughput proteomics technologies.

We are looking for a proactive and enthusiastic scientist, able to work collaboratively and communicate effectively with project teams across scientific disciplines and therapeutic areas to contribute to iterative experimental design and mechanistic hypotheses generation through the interpretation of complex proteomics data. Applicants should possess strong written and oral communication skills and the ability to work effectively in a team environment, regularly presenting internal updates and contributing to publication strategy in high level peer-reviewed journals and international conferences.

Main Duties and Responsibilities:

This role will primarily support proteomic collaborations across both Early Oncology and Biopharmaceuticals R&D. Key responsibilities will be operation and maintenance of automation platforms and liquid handling systems to ensure proteomics data is accurately acquired and analyzed. The successful candidate will have the opportunity to work and grow in a fast-paced environment under the supervision of senior staff members.

• Oversees laboratory automation, robot programming and best practices of sample preparation and data acquisition.

• Lead the development and optimization of new automated mass spectrometry technologies towards a fully automated experimental workflow.

• Lead collaborations and communicate effectively with internal and external experts from a variety of technical backgrounds.

• Demonstrate creative and independent scientific thinking to solve complex technical and scientific problems.

• Operate effectively in a multidisciplinary matrix research environment, providing leadership and insight.

Education & Experience Requirements:

Education: PhD in engineering, analytical chemistry, or proteomics or relevant field.

Experience:

PhD with 1+ years of relevant postdoc or industry experience.

Required Skills:

• Experience with proteomics workflows with an emphasis on developing automated sample preparation procedures.

• Hands-on experience with robotic liquid handling and other automation systems with demonstrated proficiency in script/method writing, preferably with Hamilton or Agilent platforms.

• Training users and transferring automation methods to project teams.

• Proven track record of leading automation projects in highly collaborative and cross-functional research environments.

• Demonstrated ability to successfully lead and advance automation projects by designing methods, analyzing and interpreting data, and summarizing results for presentations, reports, and publications.

• Experience with common programming languages such as Python, use of APIs to access instruments programmatically and establish workflows between instruments.

• Demonstrated ability to lead projects that result in high-quality scientific publications.

Desired Skills:

• Experience with sample preparation for low-input proteomics, high-throughput proteomics by DIA, or post-translation modifications analysis.

• Experience working in a matrix organization is a plus.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions.

That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.

Date Posted

11-Jul-2024

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process.

We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.