Senior Scientist, Assay Development

KSQ Therapeutics Cambridge , MA 02139

Posted 3 weeks ago

About KSQ Therapeutics

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a preclinical-stage biotech in Kendall Square that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development. We maintain a lively and inquisitive environment in the heart of the vibrant Kendall Square (KSQ) neighborhood.

Position Summary:

KSQ Therapeutics, Inc. is seeking a highly motivated Senior Scientist with a strong background in assay development to join our Oncology group. The successful candidate is expected to collaborate across our research groups to identify biomarkers and lead the development of cell-based assays to support drug discovery campaigns.


  • BS/MS with 5-10 years of experience in industry drug discovery setting, preferably in cell-based assay development
  • Familiarity with both targeted oncology and immuno-oncology assays preferred
  • Ability to identify, develop and validate biomarkers to support drug discovery programs
  • Experience with a wide range of assay techniques such as ELISA, HTRF, MSD, Luminex, Flow cytometry, NanoString, qPCR, Western blotting
  • Coordinate and manage assay transfer to external CROs if necessary, including all technical documentation and necessary control samples for validation of assay
  • Independently motivated, excellent communication and organization skills and the ability to work in fast paced, highly collaborative environment
icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Associate Scientist


Posted 2 days ago

VIEW JOBS 1/21/2021 12:00:00 AM 2021-04-21T00:00 ROLE SUMMARY Within the Internal Medicine Research Unit (IMRU), the Metabolism group is focusing on identifying targets and developing compounds for the treatment of metabolic disease including fatty liver. We are seeking motivated self-aware individuals with excellent oral and written communication skills and a deep interest in biological sciences. The successful candidate will have skill sets in cellular and molecular biology and experience in primary cell culture such as hepatocytes. Experience in in vivo and animal handling is a plus. The successful candidate will be able to learn new techniques in vitro and in vivo quickly as needed to support project. The candidate will be involved in research projects from early target validation to drug development and function in a team environment. ROLE RESPONSIBILITIES Successful candidates will be expected to: * Perform in vitro experiments to explore the mechanism of actions of potential biology targets and therapies in hepatocytes. * Analysis in vitro, ex vivo and in vivo samples to assess effect of potential biological target and therapies as well as to identify biomarkers of drug action and efficacy. * Develop and validate in vitro assays to support portfolio projects. * Quantification and translation of experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions. * Communicate and present his/her data to project team. * Maintenance of laboratory notebook records and adherence to safety policies is strictly required. QUALIFICATIONS * BA, BS or MS in Biochemistry, Physiology, Molecular and cell biology with laboratory experience in appropriate scientific areas relevant to this position. * Prior experience in culturing/isolation of primary cells i.e. hepatocytes. * Strong oral and written communication. * Knowledge in liver and lipid metabolism is desirable. * Experience in vivo is a plus. * This position will require some lifting, sitting, bending, standing, walking. Other Job Details: * Last Date to Apply for Job: February 9, 2021 * Eligible for Employee Referral Bonus #LI-PFE Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Research and Development #LI-PFE Pfizer Cambridge MA

Senior Scientist, Assay Development

KSQ Therapeutics