Senior Scientist, Antibody Engineering

Alector, Inc. South San Francisco , CA 94080

Posted 5 months ago

At Alector, our mission is to develop therapies that empower the immune system to cure neurodegeneration. Our team is solely focused on developing cures for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and board members, leading healthcare investors and some of the most innovative pharma companies.

Would you like to craft novel therapies that make a substantial difference in patients' lives? Do you desire both autonomy and teamwork in pursuing scientific challenges? Do you want to be part of a hardworking team where you would have a voice?

We are seeking a highly motivated Senior Scientist with validated expertise in biologics drug discovery to be a member of the Antibody Discovery and Protein Engineering group at Alector. You will closely work with dynamic and motivated teams to drive Alector's early discovery efforts for unmet medical needs in neurodegeneration and cancer. Expertise in phage display, library design, construction and screening is preferred. Hands-on experience and knowledge in b-cell cloning, hybridoma sequencing, protein expression, purification and/or characterization would be valuable. You should have a proven track record in demonstrating creativity, taking initiative and ability in influencing at all levels, both up and across. You will lead and participate in project teams, chip in pipeline strategy and help build creative approaches to discover and optimize antibody-based bio-therapeutics development. You should be able to thrive in a highly dynamic and encouraging yet independently thinking culture. You are expected to be pragmatic with complex science and procedures. You will need to be highly efficient in collaborating with internal team members and external partners.

During the first year, your goals will include:

  • Therapeutic antibody lead selection by phage display panning of human antibody libraries

  • Affinity maturation / optimization of antibody and fusion protein lead molecules

  • Implementation / development of state of the art antibody engineering technologies to enable first-in-class and best-in class bio-therapeutic molecules

  • Molecular cloning, PCR, mutagenesis, SDS-PAGE, western blotting, FACS

  • Protein / antibody expression in bacteria and mammalian cells

  • Protein purification

We'd love to hear from you if:

  • It would be a plus if you have hands-on experience in the following areas:

  • Immunized phage or yeast library generation

  • Yeast display and/or other display methods

  • Single B-cell cloning

  • Bi- and multi-specific antibody engineering

  • Ability to work independently as well as in a multi-disciplinary team environment

  • Ability to multi-task and change priorities based on business needs

  • Ability to adopt a culture of continuous learning and improvement and refining technical skills

  • Take a dedicated role in growth and scientific development

  • Design complex experiments and provide in-depth analysis and interpretations of diverse experimental results

  • Demonstrate in-depth, independent, scientifically-directed, and innovative thinking

  • Educational preference:

  • PhD in Biochemistry, Molecular Biology, Chemistry, Immunology, Protein Engineering or a related field with 5+ years of related industry or 8+ years of academic working experience

  • A track record of scientific accomplishments as evidenced by peer-reviewed publications, patents or pipeline contributions

  • Excellent oral and written communication skills

At Alector, we believe that high-performing teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.

Alector is a phenomenal place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a cure, where you'll drive growth, this is the role for you. There is no limit to how far you can go with us.


While we've focused on what to look forward to during the first year and beyond, Day One is great, too: committed and driven colleagues, a bold and important company goal, state-of-the-art brand-new brightly-lit offices in the heart of the biotech area, competitive compensation and benefits. But these matter only if you're excited to build and own something great, and tackle these challenges with us. Come join us.

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Senior Scientist, Antibody Engineering

Alector, Inc.