Senior Research Statistician/Manager, Statistics

Abbvie, Inc Redwood City , CA 94063

Posted 2 weeks ago

About AbbVie

AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world's most complex and critical conditions. The company's mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook or LinkedIn.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.

Discovery and Exploratory Statistics (DIVES) is part of the Data and Statistical Sciences (DSS) organization in AbbVie R&D. This group located on the West Coast provides statistical expertise for various groups in drug discovery, translational oncology, development sciences and clinical biomarkers in early stage oncology clinical trials. Examples of applications/topics supported include in vitro screening, in-vivo pharmacology, genomics, proteomics, imaging, and other biomarker data generated from pre-clinical and clinical studies.

The Senior Research Statistician/Manager, DIVES position works with discovery researchers, translational scientists, DMPK scientists and clinical biomarker leads in the design, collection, analysis and reporting of multi-dimensional biomarker data from Discovery to early stage clinical development to enable objective decision-making for each drug development program. This position will be based at AbbVie's Redwood City, CA location.

Key Responsibilities:

  • Collaborating with discover and translational biomarker scientists and clinicians and contribute to design, analysis and reporting of biomarker and assay studies in association with early and late phase clinical trials. The typical analysis includes pharmacodynamic biomarker analysis, safety biomarker analysis, prognostic and predictive biomarker identification and development, bioassay and companion diagnostic test development, patient subgroup identification based on biomarkers and clinical variables.

  • Contributing to design, analysis and reporting of biomarker-based clinical trials or other scientific research studies. Assist or work independently in developing biomarker section of clinical trial protocols or biomarker analysis plans. Implement sound statistical methodology in scientific investigations.

  • Ensuring data are sensible and comprehensive with quality for the assigned statistical analysis and deliverables.

  • Supporting and advising scientists in discovery and translational science units in the design, analysis and reporting of in vitro, in vivo pharmacology studies, and human clinical trials under supervision. Identify markers and signatures from internal/external omics/imaging and other biomarker data for target identification, mechanism of action, resistant mechanism, disease progression, patient selection and stratification for precision medicine.

  • Perform statistical analyses as per the biomarker analysis plan. Identify potential issues arising in the study design; conduct and propose scientifically sound approaches. Evaluate appropriateness of available software for planned analyses and assess pros and cons for potential development of novel statistical methodology.

  • Accountable for data presentation and inference. Collaborate in publication of scientific research. Ensure that study results and conclusions are scientifically sound, clearly presented, and consistent with statistical analyses provided. Clearly explain statistical concepts to non-statisticians. Provide responses to questions and pursue analyses suggested by data. Support communications between assigned product team(s) and functional management.

Qualifications

  • For Senior Research Statistician, MS (with 4+ years of experience) or PhD (0+ years of experience) in Statistics, Biostatistics, or a highly related field is required;

  • For Manager, Statistics position, MS (with 6+ years of experience) or PhD (with 2+ years of experience) in Statistics, Biostatistics, or a highly related field, with some applied consulting or research experience on topics related to pharmaceutical research, bioinformatics, target identification, biomarkers, and subgroup identification.

  • Strong programming skills, proficient in R and SAS. Familiarity with R shiny programming is a plus.

  • Effective communication skills, both oral and written.

  • Able to identify data or analytical issues, and assist with providing solutions by either applying own skills and knowledge or seeking help from others

  • Able to build strong relationship with peers and cross-functional partners to achieve higher performance. Highly motivated to drive innovation by raising the bar and challenging the status quo

  • Expertise in statistical methodologies such as predictive modeling and inference, machine learning methods, mixed effects models, multivariate analysis, etc.

  • Expertise in genetic, genomic and proteomics data analysis desired, including raw data processing and modeling of processed/normalized data, and familiarity with various technological platforms.

  • Pharmaceutical or related industry knowledge desired, including experience and understanding of drug development and life-cycle management in the regulated environment.

Significant Work Activities

N/A

Travel

No

Job Type

Experienced

Schedule

Full-time

Job Level Code

M

Equal Employment Opportunity

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.


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Senior Research Statistician/Manager, Statistics

Abbvie, Inc