Senior Research Scientist, Medicinal Chemistry

POSITION

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. The individual will be responsible for impacting lead optimization programs by identifying and solving synthetic and medicinal chemistry problems, creating project relevant hypotheses, interpretating SAR as well as generating insights that influence research strategies. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

EMPLOYMENT TYPE

Full-time. Location in San Diego.

KEY RESPONSIBILITIES

•      Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles

•      Design synthetic target for lead discovery, develop and execute clear synthetic routes using state-of-the-art synthetic methodologies

•      Identify, develop and apply novel enabling technologies and chemistries

•      Develop novel and creative solutions to overcome project and medicinal obstacles

•      Generate effective hypotheses to pursue, followed by experimental planning and execution

•      Make substantive conceptual contributions to the project activities and scientific strategies

•      Import new principles and concepts from other fields to establish new progress within the project

•      Present data and reports on projects status at group, and departmental meetings

•   Support the advancement of compounds through in vitro and in vivo studies to identify development candidates

PREFERRED QUALIFICATIONS

•        Ph.D. in Organic Chemistry with at least 3 years of pharmaceutical or biotech experience with a demonstrated track record of contributions to the drug discovery projects

Or

•        Master's in Organic Chemistry and 8+ years of similar experience noted above

•        Detail-oriented with excellent organizational and communication skills, both verbal and written

•        Highly self-motivated and ability to multitask, navigate and be successful in a fast-paced, highly matrixed team environment

•        Demonstrated capabilities in problem-solving and creative scientific approaches

•        Ability to prepare written and oral reports including publications and project plans, provide technical input, and make presentations

•        Knowledge of ADME, computational chemistry, SBDD, molecular and cellular bioogy and pharmacology

ABOUT IAMBIC

Iambic is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments.  The Iambic platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action.  We are focused on the advancement on our internal pipeline of clinical assets to address urgent unmet patient need in oncology and other therapeutic areas.

MISSION & CORE VALUES

The culture and work at Iambic are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are located in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.