Senior Research Associate, Screening

About Plexium:

Plexium is the premier, next-generation Targeted Protein Degradation (TPD) company focused on the discovery of TPD drugs which overcome limitations of conventional approaches to broaden the therapeutic potential of TPD. Plexium is pursuing monovalent degraders, including a new class of selective TPD drugs called "Direct Degraders." Direct Degraders are small molecules that are designed to bind to a pathogenic protein in a manner that results in selective degradation of the protein by the cell's natural protein quality control machinery. In addition to direct degraders, Plexium is pursuing molecular glue degraders. This approach also leverages the cell's natural quality control machinery, however in this case, small molecules bind to an E3 ligase, redirecting the ligase to selectively target pathogenic proteins for degradation. Plexium is pursuing drug targets that have previously been undruggable or inadequately drugged across multiple disease areas.

The company is powered by its proprietary TPD drug discovery platform, which integrates degrader chemistry design principles and screening libraries with cell-based, target-specific degradation assays, including an ultra-high-throughput screening platform, to enable the identification of drug-like, cell-permeable degrader molecules. This integrated TPD drug discovery approach has led to the discovery of novel, selective direct degraders and molecular glue drug candidates, and two unprecedented E3 ligases.

Position Overview:

Plexium's Screening group is seeking a Senior Research Associate to join a multidisciplinary team dedicated to the discovery of novel targeted protein degradation therapeutics. The candidate must have in-depth knowledge of cell culture and experience with immunofluorescence and image-based assays. This role is hands on in developing and transitioning assays from well plates to the company's high-throughput, high-content discovery platform and thereby providing high quality data to make actionable decisions in Biology and Chemistry.

Essential Job Responsibilities:

• Execute high-throughput screening campaigns

• Support development of novel techniques, assays, and protocols

• Ability to precisely follow protocols and gather data with a high degree of consistency

• Generate and analyze high-content microscopy data

• Maintain a knowledge of literature related to areas of research

• Maintain up-to-date and detailed records of experiments in an electronic notebook

Required Skills and Knowledge:

• BS/MS degree plus 5+ years of prior laboratory experience (i.e., academic, biotech or pharmaceutical industry laboratory)

• Proficiency with iPSC and neuronal cell culture

• Working knowledge of immunofluorescence, western blot, and molecular biology techniques

• Experience with image based assays

• Exceptional attention to detail

• Excellent problem-solving skills

• Exemplary communication and collaboration skills, ability to work as part of a multi-disciplinary team in a fast-paced, innovative environment, delivering to project priorities and deadlines

The US base salary range for this full-time position is $85,000 - $115,000 + target annual bonus + equity + health and well-being benefits. Our salary ranges are determined by a number of factors, including but not limited to the role, location, job-related skills, and relevant education, experience and training. The range displayed on each job posting reflects the minimum and maximum target for new hire base salaries for the position across all US locations and vary by the location of the position. Our Talent Acquisition Team can share more about our salary ranges and other benefits of working at Plexium, which are not included in the posted base salary range.

Notice to third party recruitment agencies: Plexium does not accept unsolicited resumes from recruiters or employment agencies. In the absence of an executed recruitment services agreement, there will be no obligation to any referral compensation or recruiter fee. In the event a recruiter or agency submits a resume or candidate without an agreement Plexium shall explicitly reserve the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency. Any unsolicited resumes, including those submitted to hiring managers, shall be deemed the property of Plexium.