Senior Research Associate / Scientist I, Biology

Monte Rosa Therapeutics Boston , MA

Posted 3 days ago

Senior Research Associate/Scientist I, BiologyLocation:
Boston, MA

Monte Rosas rational approach to targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and other diseases. Delivering this new generation of treatments to patients requires a conceptual change. Monte Rosa recognizes this urgent need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.

Monte Rosa Therapeutics is seeking an energetic and self-motivated scientist to join our innovative team working towards discovery of unique molecular glue degraders for the treatment of targeted patient populations in indications including auto-inflammatory disease, hematology and oncology. This is a lab-based position that offers the opportunity to impact projects as they progress from target validation and hit-finding, through to lead optimization and pre-IND studies.

The candidate will be a highly motivated experimentalist with demonstrated collaborative skills and a strong desire to contribute to project success.

Principal Duties and Responsibilities

  • Validate molecular glue degrader hits by employing techniques such as Western blot, flow cytometry, ELISA, qPCR to assess viability, target and biomarker expression, proliferation.
  • Develop, validate and independently execute cell-based assays using cell lines and primary human hematopoietic cells.
  • Participate in team drug discovery biology efforts to perform target validation, discovery toolkit development and hit-to-lead selection and progression. Opportunity to champion projects as they progress to hit-to-lead and beyond.
  • In collaboration with the team:
    • utilize literature and internal bioinformatics data to design and test hypotheses for drug targets
    • identify pharmacodynamic assays for utility in pre-clinical and clinical setting; define PK/PD/efficacy relationships and test patient selection strategies.
  • Interpret, present and report research findings at internal meetings.

Requirements

MS or PhD equivalent in Immunology, Cell Biology or Cancer Biology with 3+ years hands-on experience in drug discovery research in a pharmaceutical setting

Extensive experience with protein detection/quantitation methodology (e.g., Western blotting, JES) and antibody reagent validation required

Multiparameter flow cytometry and immune cell assay experience required (e.g. T cell proliferation assays); ex vivo cell isolation and analysis experience preferred

Prior experience preparing drug dilutions and performing drug sensitivity experiments required

Previous work with culture and maintenance of mammalian cell lines, including transfection and transduction techniques, as well as stable cell line generation; prior experience culturing/manipulating primary immune cells preferred

Ability to maintain timely and detailed notes using electronic lab notebook as well as demonstrated experience using Microsoft Excel and GraphPad Prism

Excellent interpersonal skills and willingness to learn a variety of new techniques and biological approaches; ability to work in a matrixed team and adapt to rapidly changing priorities and deadlines

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Research Associate Cancer Biology Crispr

Monte Rosa Therapeutics

Posted 3 days ago

VIEW JOBS 11/30/2021 12:00:00 AM 2022-02-28T00:00 <p>We are seeking an energetic and self-motivated research associate to join a team of scientists working towards discovery of unique anti-cancer compounds for the treatment of targeted patient populations. Role requires experience in using CRISPR/CAS9 as a tool to develop novel cellular cancer models. The candidate will be a highly motivated experimentalist with a strong desire to succeed at the highest level.</p> <p><strong>Principal Duties and Responsibilities</strong></p> <p></p> <p>Engineer cell lines with knock-out or knock-in of genes of interest using non-intergrated sgRNA and CAS9</p> <p></p> <p>Design strategies for cloning fusion reporter gene vectors, identify CROs to perform cloning and manage execution of the work.</p> <p>Utilizes lasted Molecular biology tools to NGS,ddPCR rtPCR, advance cloning techniques Golden Gate, Gibson Assembly to build genomic knock up down models.</p><p><strong>Requirements</strong></p><p>BS/MS equivalent in cell/molecular biology, cancer biology or genetics with at least 1 year hands-on experience in cancer research preferably in a pharmaceutical setting</p> <p>Experience with molecular biology methods and assays such as molecular cloning, RNA and protein expression approaches (e.g. QPCR, Western blotting) as well as various genetic perturbation methods.</p> <p>Experience in gene editing using CRISPR/CAS9, particularly strategies that use non-interfated sgRNA and CAS9.</p> <p>Ability to maintain timely and detailed notes using electronic lab notebook as well as demonstrated experience using Microsoft Excel and GraphPad Prism </p> <p>Excellent interpersonal skills and willingness to learn a variety of new techniques and technologies; Ability to adapt to rapidly changing priorities and deadlines</p> Monte Rosa Therapeutics Boston MA

Senior Research Associate / Scientist I, Biology

Monte Rosa Therapeutics