Senior Research Associate, Neuroscience Pharmacology

Voyager Therapeutics Cambridge , MA 02138

Posted 2 months ago

Voyager Therapeutics is a clinical-stage gene therapy company focused on developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. Voyager's pipeline focuses on severe neurological diseases in need of effective new therapies, including Parkinson's disease, a monogenic form of ALS called SOD1, Huntington's disease, Friedreich's ataxia, neurodegenerative diseases related to defective or excess aggregation of tau protein in the brain including Alzheimer's disease and other tauopathies, neurodegenerative diseases related to defective or excess aggregation of alpha-synuclein protein in the brain including Parkinson's disease and other synucleinopathies, and severe, chronic pain. Voyager has strategic collaborations with AbbVie and Neurocrine Biosciences. Founded by scientific and clinical leaders in the fields of AAV gene therapy, expressed RNA interference and neuroscience, Voyager Therapeutics is headquartered in Cambridge, Massachusetts.

We are seeking a highly motivated neurobiologist to contribute to the neuroscience team at our facility in Cambridge, Massachusetts. This is an ideal position for an experienced and assiduous individual with drug discovery experience, one who demonstrates individual commitment to a company vision & team effort, who thrives in a fast-paced and cross-function industry environment. The individual will work in the laboratory and be responsible for experimental execution for research studies supporting one or more cutting edge programs in neurodegenerative disease drug discovery. We are looking for a candidate with hands-on experience with rodent in vivo studies (dosing, tissue dissection and collection) and downstream analysis (e.g. RT-qPCR, ELISA, immunohistochemistry and western blot). This position reports to the Associate Director, Neuroscience.

Responsibilities include, but are not limited to

  • Execute on rodent in vivo experiments: breeding, animal handling, test article dosing via various administration routes

  • Performing perfusion, necropsy, dissections and collection

  • Involve in developing and conducting ex vivo tissue analysis (ELISA, western blot, RT-qPCR, etc.)

  • Performing data analyses and independence in data analyses

Requirements

  • BS (+5 years) or MS (+2) in either Neuroscience, Pharmacology, Biochemistry, Biomedical Science or other relevant scientific discipline

  • At least 2 years of industry experience in a fast paced pharmaceutical, biotech company within the drug discovery setting

  • Can independently manage and troubleshoot small and large rodent studies for in vivo and ex vivo endpoints. Hands-on experience with rodent handling, tissue dissection and data analysis

  • Experienced in design, documentation and execution of experiments

  • A problem-solver in the laboratory

  • Ability to be highly productive in a fluid and fast-paced work environment

  • Scientific and team-directed communication skills

Strongly Preferred

  • Familiarity with stereotaxic brain injections and OR protein microdialysis

  • Familiarity with molecular and biochemical methods, such as PCR, ELISA, western, and immunohistochemistry

  • Willingness to bring in novel tools & learn techniques of relevance to gene therapy & neurodegeneration

  • Prior experience with biologics and/or gene therapy.

  • Ability to think critically about models, therapeutic molecules and data.

  • Ability to prioritize responsibilities across multiple programs.

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Senior Research Associate, Neuroscience Pharmacology

Voyager Therapeutics