Senior Research Associate - In-Vivo Pharmacology

Agenus Lexington , MA 02421

Posted 6 months ago

The Vaccine Research team at Agenus is developing cutting edge cancer vaccines- including individualized medicines- applicable to treatment of all cancer types. The team is responsible for discovery research and IND enabling studies which inform mechanism of action of our drugs form the basis for regulatory filings and first in human clinical trials. The team is leading research on combining the cancer vaccines with Agenus's other immune modulating agents to bring even more potent therapeutic options to cancer patients. We are seeking a scientist to support the non-clinical experiments to develop the company's cancer vaccine pipeline from discovery research through IND filing.

Roles and Responsibilities

  • Meticulously execute in-vivo experiments to provide relevant data for the characterization of on Immuno-oncology drug such as anti tumor vaccines.

  • Provide feedback, insights and logistics for design and execution of the in-vivo experiments.

  • Manage the daily necessities and logistics for the smooth running of the Vaccine Research laboratory.

  • Act as a liaison between Vaccine Research (Agenus) and our onsite CRO.

  • Work collaboratively with scientists across disciplines to obtain tools and reagents needed to execute experiments.

  • Data generation, organization, analysis and presentations at group meetings and conferences.

  • Apply information obtained from current literature to develop hypotheses and design experiments.

  • Mentor and manage technical staff and other group members as necessary.

Qualifications and educations Requirements

  • 3 years' experience in tumor immunology (MS in Biology with an immunology background preferred).

  • Knowledgeable and skilled in designing and conducting cell-based assays and in vivo mouse studies.

  • Excellent written and oral communication skills as demonstrated by writing SOPs and Technical Reports.

  • Driven researcher with demonstrated experience in working on team projects and achieving goals in a timely manner.

Preferred Skills

  • Substantial experience of immunology, molecular biology, and in-vivo techniques including but not limited to multicolor Flow Cytometry, ELISPOTS, Bioluminescence Imaging, Binding assays, PCR, culturing of primary cells, Cell line generation/maintenance and Fluorescence microscopy.

  • Sharp surgical skills and manual dexterity is essential to perform procedures such as intravenous injections, intraperitoneal injections, subcutaneous injections, and xenograft transplants.

  • Strong empirical observational skills that can be translated into writing technical reports and SOPs that will support IND filings.

  • Must be a quick learner and flexible in adapting to different project settings, and the ability to adjust to working in small/large groups.

  • Interpretation and presentation of data in internal meeting and scientific conferences.

  • Proficient at Flowjo, Graphpad, Powerpoint presentations.

Competencies Needed

  • Communicates understanding of team goals and priorities.

  • Collaborative: willingness to contribute to execution of complex experiments not necessarily directly applicable to one's individual goals.

  • Comfortable with change management: adaptable in fast changing environment and flexible in order to effectively deliver results within reasonably established timelines.

  • Builds trust by demonstrating reliability and dependability.

  • Proactive: predicting needs before they arise.

  • Effective problem-solving and decision-making skills with the ability to troubleshoot experimental processes and provide analysis.

  • Good time management skills exhibited by the ability to pay attention to details while working under pressure.

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Senior Research Associate - In-Vivo Pharmacology