Senior Research Associate I/Ii - In Vivo

Overview

Monte Rosa Therapeutics is searching for a Sr Research Associate I or II in Immunology/Oncology to provide expertise in developing innovative molecular glue degraders, aiming to deliver a new generation of treatments to patients. This individual will design and execute pivotal proof-of-concept studies in pre-clinical models of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. Significant cross-functional collaboration with a talented and dedicated group of scientists including chemists, cell biologists, immunologists, will ensure a diverse exposure to the drug discovery process. This person will work primarily in our Animal Care Facility, with an opportunity to expand their scope at the lab bench.

Responsibilities

• Perform basic and intermediate veterinary technical tasks in mice independently, including the following:

• Administration of selected agents by PO, IP, IV, IM, SC routes.

• Blood sampling techniques via multiple routes, including submandibular bleed.

• Tumor implantation on flank, followed by tumor volume measurements.

• Preparation of compound formulation for in vivo

• Optimize and perform studies to define target biology in mouse models of inflammation and immunity for in vivo, in vitro and ex vivo

• Maintain accurate laboratory records/notebooks, procedures, and data summaries.

• Generate high-quality data reports and provide suggestions for future work to management and project teams.

Qualifications

• BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.

• AALAS certification at the ALAT level is preferred. Uncertified candidates must obtain ALAT certification within 12 - 18 months or demonstrate substantial progress toward certification. LVT qualification is a plus.

• Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.

• Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.

• Experience in culturing mammalian cell lines is advantageous.

• Experience with pharmacodynamics assays of mouse tissue, including Western Blotting, ELISA/Mesoscale and flow cytometry is a plus.