Senior Research Associate, Dmpk-Ndcp

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

• Develop LC-MS/MS methods and analyze in vitro and in vivo samples to support ADME, pharmacokinetic, and toxicokinetic studies.

• Perform data analysis, provide reports of experimental results, and upload data to electronic system and electronic notebook.

• Conduct in vitro metabolic stability studies in bio-matrices, including hepatocytes, microsomes, blood, plasma, etc.

• Perform in vitro ADME/DMPK assays, such as CYP inhibition, metabolic profiling, etc.

• Assist in the operation, maintenance and troubleshooting of LC-MS/MS instrument.

Required Skills, Experience and Education:

• Bachelor/Master's degree in Pharmaceutical Sciences or a related scientific discipline, with 5+/3+ years of industry experience.

• Hands-on experience in operating and maintaining an LC-MS/MS system.

• Hands-on experience in LC-MS/MS method development and bioanalytical analysis.

• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS analysis.

• Hands-on experience in HPLC/UPLC method development.

• Ability to conduct multiple laboratory and project tasks efficiently.

• Ability to work in a team-oriented environment with flexibility.

• Highly organized, detail-oriented, excellent record-keeping skills, and being able to adapt to a dynamic and fast-paced environment.

Preferred Skills:

• Previous hands-on experience in SCIEX QTRAP and/or Thermo Q Exactive mass spectrometers .

• Working experience in DMPK lab.

The expected salary range for this role is $95,000 to $120,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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