Bighat Biosciences San Mateo , CA 94401
Posted 4 weeks ago
The Role: BigHat Biosciences is seeking a self-motivated Senior Research Associate to join the Display Technologies team. This individual will expand BigHat's ability to discover novel, next-generation antibodies, and to generate data to improve BigHat's machine learning models using display. The Role: BigHat Biosciences is seeking a self-motivated Senior Research Associate to join the Display Technologies team. This individual will expand BigHat's ability to discover novel, next-generation antibodies, and to generate data to improve BigHat's machine learning models using display.
Key Responsibilities
Constructing phage display libraries to use for selections (PCR, molecular cloning, electroporations).
Performing phage display selections using naive and affinity maturation libraries to discover novel next-generation antibodies.
Expressing, purifying, and characterizing display-derived molecules using a suite of assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
Analyzing results from display selections to guide next steps and future experiments.
Driving process improvements to make the display workflows more efficient, robust, and scalable.
Collaborating with BigHat's Data Science and Machine Learning teams to facilitate data transfer and analysis to further bolster library design and machine learning model training.
Keeping a detailed record of all experiments using BigHat's documentation tools, and clearly communicating results and challenges.
Presenting experimental plans and results during regular meetings with manager and science teams.
Skills Knowledge and Expertise
B.S. with 2+/4+ or M.S. with 1+/3+ years of work experience.
Extensive experience with phage display workflows.
Experience with general molecular biology tools (PCR, Molecular Cloning, Mutagenesis) and developing/executing antibody binding assays.
Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment.
Good record keeping skills using LIMS and electronic notebooks.
Excited to work with diverse, cross functional teams to onboard new assays and disseminate results.
Nice-to-haves include previous experience with other display modalities (ribosome, yeast, mammalian), NGS prep/analysis of display campaigns, and experience using automation for high-throughput assay development.
Bighat Biosciences