Senior Research Associate, Cellular Analytical Development, Gene Editing - 2128

Editas Medicine Cambridge , MA

Posted 2 months ago

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. Were focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. Were looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

Key Responsibilities & Accountabilities:

  • Perform assay development, optimization, and initial qualification ofcellular analyticalmethods.
  • Work collaboratively with other groups such as Research and Process Development to generate data to support process development, formulation studies, stability studies, and characterization of drug substance and/or drug product.
  • Perform technical transfer of analyticalmethods to Quality Control or external CROs.
  • Support testing of reference standards, lead stability samples, forced stability samples, toxicology lots, non-human use (NHU) engineering runs, and clinical manufacturing runs, as appropriate.
  • Document all experimental work, supporting information, and data in an electronic lab notebook (eLN) in a timely manner.
  • Compile and present data and assist in authoring and reviewing of test methods, technical reports, and supporting procedures for new and existing programs.
  • Cross-train personnel on assays, as required, and provide guidance to junior research associates.

Requirements

Knowledge, Skills & Capabilities:

  • Experience withaseptic technique and cellculture,preferably with human cell lines and stem cell differentiation.
  • Experience withlive cell analytical methods including cell counting and flow cytometry, and molecular techniques such as nucleic acid isolation and qPCR/ddPCR/RT-PCR.
  • Experience with development and qualification of cell-based assays a plus.
  • Strongorganizational skills with the abilityto multi-task, problem-solve,prioritize assignments,andadjust prioritiesto meet goalsin afast-pacedenvironment required.
  • Attention to detail and the ability to work individually, within a multi-disciplinary team in a matrix environment, as well as with external partners and vendors.
  • Strongverbal and written communication skills.
  • Familiarity with FDA, USP, and ICH regulations, industry standards and quality control principles for GMP operationsand experience withdevelopmentor technical transferofGMP analytical methods for cellular therapies preferred.

Education & Relevant Work Experience:

  • Bachelors degree in a life science discipline such as Biological Sciences, Biotechnology, Pharmaceutical Sciences, or Biomedical Engineering with 5+ years of relevant experience or Masters degree with 2 years of experience.
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Senior Research Associate, Cellular Analytical Development, Gene Editing - 2128

Editas Medicine