Senior Programmer, Pharmacometrics

Senior Programmer, Pharmacometrics

Categories: Clinical Pharmacology

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Senior Programmer, Pharmacometrics plays a key role in the Clinical Pharmacology department and is responsible for programming of quantitative analyses in support of internal decision-making and regulatory submissions. This position works closely with the Clinical Pharmacology and pharmacometrics program leads as well as cross-functional team members and external partners to deliver success across all phases of development. Quality control and efficiency are essential. This is a remote (US) based position.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Produce real-time analyses to support ongoing study decision-making (interim analyses, Safety Review Committee, etc.)

• Provide exploratory data analyses to support modeling and simulation

• Understand data via graphical and tabular summaries

• Run innovative analyses to help understand potential modeling approaches

• Develop processes for effective figures and data visualizations

• Build out internal capabilities for data visualizations

• Develop process to generate iterative interim figures for rapid interpretation.

• Deliver final high-quality outputs for submissions, presentations, and publications.

• Create dynamic and/or interactive displays to inform and influence stakeholders.

• Create analysis-ready datasets for NCA, population PK, PK/PD, and exposure-response analyses.

• Build analysis datasets from CDISC or interim sources.

• Conduct data cleaning and develop QC processes.

• Deliver specifications and define documentation.

Education and Experience:

• Bachelor's or Master's in a relevant scientific field with 5+ years of experience programming in the pharmaceutical industry. Direct pharmacometrics-related programming experience is a major advantage.

• Substantial experience creating analysis-ready modeling datasets for NONMEM and/or Phoenix NLME.

• Understanding of SDTM and ADaM datasets including ADNCA and ADPPK

• Experience with validation of R, SAS, or other software is desired.

• Must possess graphical programming skills.

• Clinical drug development and clinical pharmacology knowledge desired.

• Ability to work cross-functionally with data managers, programmers, statisticians, and external partners.

• Strong written, presentation and verbal communication skills.

• Expertise in R programming required, SAS programming skills desired. Windows, MS Office (Outlook, Word, Excel, PowerPoint), GraphPad Prism.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: $96,000-$128,000

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Vaccination requirement:

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.