Senior Principal Biostatistician

Agios Pharmaceuticals Cambridge , MA 02138

Posted 3 months ago

Senior Principal Biostatistician

Agios ( is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are growing rapidly with an active research and discovery pipeline across multiple therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development.


Agios is seeking an innovative Senior Principal Biostatistician for our Biostatistics team. Our statisticians lead, develop and implement statistical solutions to support all phases of clinical trials and influence decisions across our oncology and the rare genetic disorder platforms. The successful candidate will function as an independent program statistician across multiple clinical development programs, and will supervise study level statisticians/programmers at CROs.

Agios Statisticians are accountable for all biostatistics study deliverables and manage key trial responsibilities including: statistical design of all phases of trials, authoring of SAPs, and conducting just-in-time analyses and data exploration. The successful candidate must possess the desire and ability to work with study teams up through and including leadership responsibilities as part of our growing, evolving group.

Key Responsibilities:

  • Serve as a statistical and project manager for biostatistics deliverables across assigned clinical development programs

  • Ensure that clinical development programs (or parts assigned) meet scientific, regulatory, and quality requirements

  • Oversee outsourced biostatisticians/programmers as needed

  • Perform trial statistician responsibilities including attendance of study team meetings, authoring SAPs, reviewing CRFs, design of phase 1-3 and PK studies, review of protocols/amendments, conducting exploratory data analyses, and performing just-in-time analyses

  • Apply innovative statistical approaches to study design, analysis and data exploration methodologies, including Bayesian adaptive methods to dose finding

  • Plan and track study level activities within programs, including resources; ensure CRO timelines and objectives are met

  • Help to maintain Agios data standards, within and across programs (e.g. standardization of CRFs, outputs, SAPs)

  • Plan and manage submission activities, like SCS, SCE, briefing books.

  • Serve as a general clinical development and statistical resource at Agios; participate in non-clinical project activities

Minimum Requirements:

  • PhD in Biostatistics and 2+ years in biopharmaceutical industry as a biostatistician

  • MS Biostatistics and 6+ years in biopharmaceutical industry as a biostatistician

  • Fluent in English (oral and written)

  • Prior Experience with regulatory submissions

  • Proven knowledge and expertise in statistics and its applications to clinical trials

  • Fluent with statistical software including SAS, R, EAST, among others

  • Proven ability to work independently

  • Excellent communication and presentation skills

  • Team player, with ability to work successfully across functions

  • Innovative, flexible mindset

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Or Principal Scientist Computational Biology

Apex Systems

Posted 2 days ago

VIEW JOBS 1/24/2020 12:00:00 AM 2020-04-23T00:00 Job Description Job #: 1017100 Senior/Principal Scientist, Computational Biology 1017100 Job Scope & Purpose: The growing discovery team at our publicly held biopharma client is seeking an experienced Computational Biologist/Bioinformatics scientist that specializes in cancer immunotherapy. You will play a key role in the target identification/validation of new targets and further analysis of data sets. You will build the company's bioinformatics capabilities focusing on the analysis of internal data and public databases to identify novel potential targets in the Cancer Immunology field. The successful candidate will join the Discovery Research team and be responsible for establishing bioinformatics pipelines and analyzing data sets that include but are not limited to: bulk and single-cell RNA-seq, DNA-seq and ATAC-seq, unsupervised/automated HD flow and mass cytometry analyses, and Multiplex Cytokine data. Primary Job Responsibilities: * Make important contributions to our proprietary drug discovery programs by interrogating genomics, transcriptomics, and other omics datasets. * Work collaboratively with experimental scientists to characterize novel targets, and use NGS approaches to characterize our novel proprietary T cells * Serve as a member of multidisciplinary project teams that bring together our Translational Biomarkers, Immunology, Molecular Biology, Protein and Cell Sciences, and Innovation groups * Lead the experimental design, analysis, and interpretation of DNA and RNA sequencing experiments in support of discovery and preclinical research programs * Inform the identification of novel tumor-associated antigen targets by identifying, analyzing and interpreting external data and knowledge resources * Define immune cell signatures from public data that can be used to compare to novel T cells in the TME * Work with open-source and commercially available software platforms for the processing, analysis, and mining of DNA/RNA and other omics data. Primary Job Requirements: * Ph.D. or M.S. in Computational Biology, Biostatistics, Bioinformatics, Computer Science, Genetics, Mathematics, Physics * Required Experience and Skills: * A minimum of 2 years experience in a biotech/pharmaceutical setting * Strong background in bioinformatics, statistics, data modeling, and cancer genomics * Demonstrated experience in the computational analysis and interpretation of large-scale DNA and RNA sequencing datasets (bulk and single-cell) * Proficiency in R, PEARL and Python programming languages * Strong communication (oral and written) skills * Excellent attention to detail and high self-motivation; capability to prioritize deliverables among multiple simultaneous projects * Background in immunology and cancer immunotherapy * Experience analyzing high dimensional Mass and Flow Cytometry data sets * Machine learning experience * Familiarity with multi-omic data integration * Strong publication record About Stratacuity: Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent. PROVEN SCIENTIFIC PLACEMENT™ Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us. [ Link Removed ] Code: DiscDevt EEO Employer Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at [ Phone number blocked ] . Apex Systems Cambridge MA

Senior Principal Biostatistician

Agios Pharmaceuticals