Senior Manager, Upstream Operations

Kite Pharma, Inc. Oceanside , CA 92049

Posted 6 days ago

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job

Job Description

Kite has an opportunity for an experienced candidate in Manufacturing Operations at our Oceanside facility in Southern California. We are seeking motivated, team oriented individuals with expertise in viral vector production. The qualified Upstream Lead will perform hands-on execution of all aspects of upstream operations in GMP manufacturing support.

Specific responsibilities and skills for Position:

  • Knowledge of cell culture scale-up and engineering principles (e.g. growth rates, specific consumption/production rates, bioreactor aspect ratios, power calculations, gas transfer, shear stress)

  • Applicant should be an effective communicator of ideas and results and should have the ability to proactively identify issues and suggest solutions in a collaborative multidisciplinary environment

  • Candidate should be self-motivated, ambitious, organized, and collaborative

Responsibilities:

  • Maintain multiple seed trains in shake flasks and bioreactors

  • Build, operate, and troubleshoot bench top and bioreactors; compile and analyze results

  • Work with support functions to ensure equipment stays in peak working order

  • Maintain a clean, organized, and uncluttered work area, and proper discretion with raw material sterilization and handling.

  • Write and edit batch records, work instructions, and campaign reports

  • Identify opportunities for future process and equipment improvements

  • Collaborate with the other functional groups to ensure successful tech transfer and execution of GMP operations

  • Act as an effective and committed team player

  • Demonstrate a strict adherence to safety and environmental and regulatory compliance

  • Responsible for driving continuous improvement in all operation processes

Essential Functions:

  • Selects appropriate methods and techniques in performing operations.

  • Recommends alternatives, researches new methods and techniques and proactively seeks out senior personnel to discuss potential solutions to problems.

  • Participates in group meetings. Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.

  • Demonstrates good verbal communication and interpersonal skills to provide insight into the processes used to achieve results of assigned tasks.

  • Demonstrates ability to recognize anomalous and inconsistent results and interpret experimental outcomes.

  • Develops skills in data analysis and ability to evaluate quality of data.

  • Works with collaborative and problem solving spirit.

  • Always works with safety in mind.

Knowledge, Experience, and

Skills:
  • 12+ years of experience with BS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline

  • 10+ years of experience with MS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline

  • Experience in Cell Culture Pilot Plant, MSAT, Development, and Manufacturing role(s)

  • Experience with cell banking through scale-up and primary recovery (centrifugation and depth filtration). Mammalian and/or microbial fermentation experience is desired.

  • Experience with bioreactor control systems is an advantage

  • Hands-on experience with large-scale bioreactor operation is a plus

  • Willing to flex schedule to perform weekend operations

  • Consistent positive attitude and demonstrated ability to learn new skills

  • Exhibits accountability, including taking ownership for words and actions and fulfilling commitments responsively

  • Ability to lift 40 lbs repeatedly and stand for hours at a time

#LI-MH1

#IND123

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'EEO is the Law' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT

YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.


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Senior Manager, Upstream Operations

Kite Pharma, Inc.