Senior Manager, Biostatistics, Early Clinical Development

Pfizer Cambridge , MA 02138

Posted 3 months ago

ROLE SUMMARY

Responsible for ensuring sound statistical thinking and methods are utilized in the discovery and development of new biomarkers. Bring the principles of objective decision-making into the development, validation and implementation of industry-leading mobile/digital technology programs for incorporation into clinical trials. Integral member of a matrixed team, which develops and uses computational and statistical approaches to discover and validate digital biomarkers.

ROLE RESPONSIBILITIES

  • Collaborate with various scientists in the design, analysis and reporting of clinical experiments.

  • Ensure rigorous approaches are taken to ensure good scientific practices are followed: excellent statistical methods utilized and documented in protocols, analysis plans and manuscripts, and assay methods are appropriately blinded, randomized and designed to meet clear objectives

  • Core member of scientific teams responsible for determining strategy and delivering results in a timely and high quality environment.

  • Interact with internal and external experts to assure sound quantitative approaches are applied to collection and analysis of a wide variety of data types.

  • Bring innovative statistical thinking and methods to help drive data-driven drug discovery and development employing modern methods including Bayesian techniques

  • Work with scientists to understand the biology and improve existing or derive new endpoints, utilize prior information, develop 'fit-for-purpose' statistical models

  • Use statistical expertise to prepare both internal and external reports, presentations, manuscripts

QUALIFICATIONS

MSc (PhD preferred) in Statistics, Biostatistics or in quantitative discipline such as Physics, Applied Mathematics, Bioengineering, Electrical Engineering coupled with high level of statistical expertise. Research experience with mathematical/statistical modeling using complex data and five or more years of postdoctoralor industrial experience are preferred.

  • Strong background in experimental design and statistical analysis including good understanding of inference and probability, competence in contemporary linear and predictive modeling including (longitudinal) mixed models, nonlinear regression, and predictive modeling

  • Pharmaceutical applications desired, with early clinical (phase I and phase II) and translational experience a definite advantage.

  • Expert level knowledge of machine learning algorithms with robust feature selection and optimization

  • Knowledge of methods of signal processing including image segmentation and/or electrophysiological data analysis

  • Genuine interest in biology and pharmaceutical development, with the attitude of self-directed scientist; demonstrated ability to multitask

  • Outstanding communication skills; ability to explain statistical and modeling concepts to non-experts

  • Demonstrated ability towork effectively as a part of a team

  • Technical Skills

  • Fluency in R programming

  • Programming in Python is a plus

  • Knowledge of MATLAB is a plus

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Other Job Details:

  • Last Date to Apply for Job: October 15, 2018

  • Eligible for Relocation Package: yes

  • Eligible for Employee Referral

    Bonus:
    yes

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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Senior Manager, Biostatistics, Early Clinical Development

Pfizer