Senior Engineer, Upstream Process Development

Sutro Biopharma, Inc. is seeking a self-driven, passionate and experienced technical leader to join its Upstream Process Development group. This individual will be part of the Platform team that works cross-functionally, in a fast-paced environment to develop Sutro's second generation novel cell-free protein synthesis process (XpressCF+) to achieve pivotal cost of goods (COGs) reduction. The production process for Sutro's cell-free extract (XtractCF), including spray drying, and lysate recovery may also be investigated for improvements and robustness. Work may also include technology transfer to internal and/or external Manufacturing sites.

Responsibilities:

The successful candidate will design and execute cell-free protein synthesis experiments to develop new processes that are translatable to the manufacturing scale. Responsibilities include the following:

• Operating bioreactor equipment over a large range of scales (250 mL - 200 L)

• Evaluate process capabilities to develop and implement process and yield improvement opportunities of XpressCF+, without compromising product quality

• Use comprehensive understanding of chemical engineering principles for the scale up of unit operations from bench to commercial scale

• Technical review of data, prepare technical reports and presentations to communicate experimental outcomes to internal teams and senior management, and to author internal and external publications

Qualifications:

We are seeking a highly motivated team-player with excellent problem-solving skills and experience with bioprocesses, scale-up and technology transfer. A passionate researcher with a knack for technology innovation to improve performance and efficiency. Versatility is a must, as tasks will involve a range of reactors, scales and process modes. Good organizational skills and the ability to manage tasks within a timeline are essential.

The ideal candidate with the following experience is required:

• Ph.D. with 10+ years of industry experience or M.S./B.S. with 15 to 20 years of experience in Chemical Engineering, Bioengineering, Biochemistry, or a related discipline

• Laboratory scale process equipment, especially bioreactors for microbial and/or mammalian culture

• Bioprocess development (cell-free, microbial, and/or mammalian cell-based)

Experience with the following is preferred:

• Scale-up and technology transfer to manufacturing sites

• Continuous or perfusion bioprocessing

• Cell-free protein synthesis

• Spray drying macromolecules (proteins, nucleic acids, and/or liposomes)

• Design of Experiments

• cGMP bioprocessing

Sound exciting? Apply today and join our team!

Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.

The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma's California-based locations will be $160,000 - $185,000. The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry, and education.

About Sutro Biopharma

Sutro Biopharma, Inc., is a clinical-stage company relentlessly focused on the discovery and development of precisely designed cancer therapeutics, transforming what science can do for patients. Sutro's fit-for-purpose technology, including cell-free XpressCF, provides the opportunity for broader patient benefit and an improved patient experience. Sutro has multiple clinical stage candidates, including luveltamab tazevibulin, or luvelta, a registrational-stage folate receptor alpha (FolRα)-targeting ADC in clinical studies. A robust pipeline, coupled with high-value collaborations and industry partnerships, validates our continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.