Senior Chemometrics Engineer

Site Name: Belgium-Rixensart, USA - Massachusetts - Cambridge

Posted Date: Jun 20 2024

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people over the next 10 years.

The CMC Applied Data Science (CADS) group, part of the Digital and Data (D&D), is responsible for all areas of data science, computational science and modelling to support technical process and product development of new vaccines and drugs products at GSK. Our responsibilities include analysis & modelling of molecular structure data, analysis of complex high-dimensional biological datasets (bioinformatics and genomics), AI/ML applications in process/product development, Chemometrics and analysis of spectral data generated by a vast array of instruments, as well as modelling of production processes. Within CADS, the CMC Chemometrics Delivery team scope is to develop proof of concepts to production-ready data science products combining recent advances in the Chemometrics domain (Spectroscopy, chromatography, time series, …) with top of research and industry software development standards.

As a Senior Chemometrics Engineer within CMC Chemometrics Delivery, you will be part of a cross-functional team solving various challenging tasks with the aim of pushing the boundaries of GSK capabilities. You will talk directly with scientists in the labs to understand their needs but you'll be involved as well in strategic decisions with leadership teams. You will be one of the reference people within the team to maintain Chemometrics pipelines and improve the best practices related to Chemometrics software development. Finally, you will work closely with experts in data management, scientific software engineering, automation, statistics or other fields of data science to turn each project into business impact.

Your responsibilities:

• You deliver end to end data science projects in all relevant areas, esp. spectra, hyperspectral and chromatograms processing, models building and their deployment in the context of biological processes, high-dimensional data analysis and Process Analytical technology (PAT).

• You identify new opportunities for application of innovative data analytics approaches for our business partners, by establishing close and productive relationships with stakeholders in your physical location and across the company.

• You coach the junior members of the team and help scientists to upskill.

• You collaborate with your colleagues on innovative Chemometrics/ML approaches to solve complex problem.

• You contribute and co-author reports for regulatory authorities, scientific papers, congress reports or other relevant communication material for internal and external stakeholders, and/or for the wider scientific community (when relevant).

• You communicate CMC Applied Data Sciences (CADS) activities, results, and principles to internal stakeholders, translating complex solutions into simple, clear and effective messages.

• You represent CADS and D&D as an Chemometrics or PAT subject matter expert in cross-functional projects teams.

• You lead initiatives to drive continuous improvement of Chemometrics projects quality and efficiency especially topics related to CI/CD.

• You work closely with our scientific software delivery team to turn scientific applications into well-designed and validated scientific applications to be used by our stakeholders.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• University degree (MSc) in Chemometrics, Machine Learning or equivalent experience with strong background in spectra data analysis, multivariate statistics, Analytical methods qualification.

• At least 5 years of working experience in Chemometrics and directly related fields

• Experience in the use of advanced chemometrics methods for process modeling (MSPC, MCR) and 'data wrangling' for signal processing and feature extraction.

• Understanding of statistical aspects linked to ICH Q8, Quality by Design (QbD) and Process Analytical Technology (PAT) principles.

• Experience with bioassays and analytical techniques, e.g. Infrared, Near Infrared, Raman, Fluorescence 3D, Hyperspectral Camera, Capacitance, HPLC, LC-MS, Electrophoresis

• Experience using standard industry software such as SIPAT or Process Pulse platforms

• Strong programming and data analytics skills. Good knowledge of Python and/or MATLAB. Familiarity with software development support tools (e.g., Azure DevOps)

• Good communication skills, ability to simplify complex problems and communicate complex solutions in a simple and effective manner

• Ability to influence performance in a matrix organization through negotiation and communication

• Experience mentoring junior data scientists

• Fluent English

Preferred Qualifications:

If you have the following characteristics it would be a plus:

• A PhD in Chemometrics, Machine Learning or equivalent experience with strong background in 3D spectra data analysis, multivariate statistics, Design of Experiments, process optimization and Analytical methods qualification.

• Good networking skills and fluent interactions with one or more scientific communities

• Good leadership skills in a scientifically oriented environment

• Good business understanding of the pharmaceutical industry

• Knowledge of general deep learning and predictive modelling, including CNNs, RNNs, time-series analysis and general techniques such as SVM, random forest.

• Experience with biological process development

• Experience with SIMCA and SIMCA Online

• French or Italian is a plus

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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