Senior Bioinformatics Scientist, Oncology

Do you want to join one of the fastest-growing molecular diagnostics startups and develop products that can affect the lives of millions?

BillionToOne, ranked at the top 5% of Y Combinator companies with $300M+ in funding from prominent VC firms, has developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000 fold. BillionToOne's first product, UNITY is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for common and severe recessive gene disorders and chromosomal abnormalities, as well as fetal sex and fetal antigens, from a single tube of blood from the pregnant mother without paternal testing.

In 2023, BillionToOne launched two liquid biopsy products that will markedly improve oncology treatment and care. With Northstar Select, clinicians will be able to select cancer therapies that will be most effective to each patient based on their individual genetic makeup. Northstar Response will enable clinicians to monitor a patient's early response to these cancer therapies, by measuring minute changes in their ctDNA, which can reduce ineffective treatments and unwanted toxicity, lower costs, and substantially improve clinical outcomes.

We are looking for a Senior Bioinformatics Scientist to create computational tools and analyze ground-breaking molecular diagnostics data. This person will be responsible for the generation, analysis, and communication of clinical next-generation DNA sequencing data for the Northstar oncology product. Our sample volume is growing extremely quickly, and this role will own the further development of our analysis pipeline to analyze tens of thousands of samples, and be the lead scientist for everything related to our bioinformatics analyses. The Senior Bioinformatics Scientist role is a full-time onsite position in our Menlo Park office.

Responsibilities:

• Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples

• Analyze and troubleshoot clinical NGS data

• Analyze our assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests

• Design new quality metrics and processes for clinical molecular diagnostic assays

• Collaborate with R&D scientists to generate new scientific insights

• Communicate assay performance and capabilities to clinical personnel at weekly meetings and to external stakeholders, clinicians, and scientists, at conferences

Requirements:

• PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related field

• 3-5 years of biology or bioinformatics research experience (during PhD or afterward)

• 2-3 years of experience analyzing NGS data (during PhD or afterward)

• Expertise in Python, R, or a similar programming language

• Experience using data structures, command-line tools, shell scripts, industry tools (GitHub, AWS, Heroku)

• Excellent communication and presentation skills, ability to work across functional teams and with non-experts.

Nice-To-Haves:

• Start-up experience

• Biophysics, Molecular biology (DNA purification, PCR, electrophoresis) or next-generation DNA sequencing laboratory experience

• Experience analyzing molecular oncology NGS data

Benefits And Perks:

• Working with a team of 'rockstars' who bring out the best in everyone

• Open, transparent culture that includes weekly Town Hall meetings

• The ability to indirectly or directly change the lives of hundreds of thousands patients

• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%

• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)

• Retirement savings program including a 4% Company match

• Free daily on-site lunches provided from top eateries

• Latest and greatest hardware (laptop, lab equipment, facilities)

• A variety of perks on campus (state of the art gym, restaurant)

• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses) (2) generous equity options offering, on top of (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid paternal leave etc.).

For this position, the base pay range is: $150,000-$170,000 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.