Senior Bioinformatics Scientist

Invitae is seeking Bioinformaticians to join our team. This role will be centered around creating workflows, tools and algorithms to complement assay/product development. The ideal candidate should be able to deconstruct a problem statement into components which can be resolved programmatically. Having a comprehensive grasp of genomics and next generation sequencing will be key to succeeding in this role. The candidate should be independent, well organized and collaborative with clear communication skills. In addition, the ability to frequently switch between tasks will be helpful.

As necessary, but not as a primary role, the candidate will assist the Clinical team in ad-hoc analysis and research required to meet regulatory requirements. You will be responsible for scaling our pipelines as we work toward our goal of providing low-cost genetic answers to billions of people.

What you'll do:

• Develop high-performance bioinformatics workflows that can accurately and reliably analyze large volumes of NGS data using Nextflow in a system agnostic manner

• Collaborate in a cross-disciplinary team by building, deploying, and maintaining software solutions compatible with distributed and/or containerized systems

• Designing APIs using industry best practices to streamline communication between various Invitae platforms

• Develop best practices for analysis of NGS data including optimization of parameters, resource utilization, and consensus approaches across various NGS applications

• Mentor team members in a wide range of bioinformatics algorithms and the utilized statistical/probabilistic techniques, including awareness of accuracy, efficiency, assumptions, and limitations.

• Mentor budding engineers/scientists by participating in code review/analysis sessions

• Drive genetics assay method development in a cross-disciplinary setting by critically analyzing and deriving insights from experimental data (including NGS, arrays, and novel technologies) using open source NGS tools and building custom tools when needed

• Develop reproducible analysis for research and development purposes

• Review, understand, and stay in compliance with Invitae HIPAA Security policies and procedures

• Optionally, build and evaluate algorithms and statistical models to improve existing genetics applications within and beyond NGS technologies and create novel ones

• Optionally, maintain a visible profile in the Bioinformatics community through publications, conference presentations, and collaborations

What you'll bring:

• Typically requires a minimum of 8 years of related experience with a Bachelor's degree; or 6 years and a Master's degree; or a PhD with 3 years experience.

• Preference is a Masters with 8+ years experience or PhD with 5+ years experience in Bioinformatics or Computational Biology

• Fluent in R/Python, *nix, and SQL like DB technology for data analysis

• Working knowledge of variant detection algorithms and the underlying models

• Working knowledge of standard bioinformatic tools used in NGS pipelines

• Working knowledge of pipeline workflow engines: Nextflow, Snakemake

• Strong knowledge of Genomics and Molecular Biology

• Solid understanding of Illumina sequencing technologies and metrics

• Formal software development experience (preferred)

• Understanding of Cloud Computing (preferred)