The Inflammation and Immunology Research Unit (I&I) is committed to finding and developing effective therapies for major diseases in the fields of rheumatology, gastroenterology, and dermatology. I&I's Leukocyte Metabolism discovery laboratory is a highly energetic group of scientists who are finding new candidate therapeutics for these diseases by understanding and targeting critical metabolic pathways in pathogenic immune cells. The responsibilities of this position are to generate laboratory data that will be critical for the team's validation of new and exciting immunometabolism targets, and to serve as a strong technical resource in the laboratory on key assays and protocols. Some laboratory research experience, preferably in immunology or a related field, is required. Excellent communication and interpersonal skills, and the ability to work effectively as part of a team are essential qualities of the role.
Contribute laboratory/technical expertise to drug discovery programs, particularly those in the early discovery phases.
Apply technical laboratory skills to the development of biological rationale for drug candidate programs, and deliver high-quality experimental data to project teams.
Isolate and culture primary immune cells; manipulate targets in these cells using knockout and/or knockdown approaches or small- or large-molecule tool inhibitors; and analyze these cell populations using standard immunological techniques eg, flow cytometry, immunoblotting, cytokine analyses, etc.
Read and stay abreast of relevant immunology literature, and contribute to discussions of this literature in the Leukocyte Metabolism laboratory group and the I&I RU.
BA/BS degree, plus 1-2+ years of research experience in a pharmaceutical, biotech, or academic laboratory.
Demonstrated experience producing high quality laboratory data in a biological field of study, preferably immunology.
Experience with the assays, techniques, and instrumentation required for studying primary immune cells preferred, but not essential.
Ability to function in a highly matrixed R&D organization.
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N (Other) (United States of America)
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