Senior Associate Scientist For Immune Modulation And Lead Characterization

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist for Immune Modulation and Lead Characterization located in Spring House, PA.

The Senior Associate Scientist position is a laboratory-based role in the Immune Modulation and Lead Characterization group within Biologics Discovery. The core job of this position is to develop and perform functional assays to support large molecule drug discovery, especially in immunology and oncology. Successful candidate will establish a process to test lead therapeutic molecules for functional activities related to T cells, macrophages, or other key cells in the tumor microenvironment. You will interface with project leaders, contribute to the assessment of the projects' needs for target characterization and relevant assay formats, and conduct experiments in a fast-paced environment. This position demands a good understanding of the biological challenges facing multiple therapeutic areas as well as technical proficiency in the latest methodologies.

Primary responsibilities:

• Co-ordinate and perform experiments to assess functional activities of lead molecules relating to T cells, myeloid cells, tumor cells, stromal cells or other key cell types.

• Co-ordinate and perform experiments to validate new targets and drug concepts. Common techniques include primary cell isolation and culture, flow cytometry, ELISA, MSD, tumor cell cytotoxicity, immune cell isolation from whole blood or tissues, reporter assays, high-content or Incucyte-based imaging and Western blot.

• Analyze and present data in professional publication-ready format.

• Keep up-to-date with the literature in field

• Working under limited supervision with a high level of autonomy