Senior Associate / Principal Associate Scientist, Translational Biology

Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company's non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio's manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

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SUMMARY

Generation Bio is seeking an energetic and adaptable Senior Associate Scientist/ Principal Associate Scientist to join our Translational Biology Team. This lab-based position will involve implementation of in-vitro and ex-vivo assays to advance our non-viral gene therapy platform and characterize leads for our growing pipeline. The ideal candidate will have a background in mammalian cell culture, chromatography, and assay development and the ability to implement new methods and work collaboratively in a fast-paced research environment.

RESPONSIBILITIES:

• Develop protocols, execute experiments, analyze data and interpret results with minimal supervision.

• Optimize and execute methods to assess expression & functional activity in tissue samples, plasma/serum, and cells.

• Culture mammalian cell lines and primary cells.

• Document experiments and present data to project teams.

• Contribute to general lab operations.

QUALIFICATIONS:

• BS. with a minimum of 2 years of related experience or M.S. with in cell biology, biochemistry or related field. Gene editing research experience a plus.

• Experience in mammalian cell culture; experience with primary cells a plus.

• Experience in gene delivery methods (e.g. transfection or electroporation).

• Experience in chromatography methods, preferably high-performance liquid chromatography (HPLC).

• Excellent lab technique and the ability to work independently.

• Analytical thinker with problem-solving skills and the ability to independently analyze and interpret data.

• Strong verbal and written communication skills.

• Ability to support and manage multiple projects in a fast-paced work environment.

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.