Scientist/Sr. Scientist, In Vivo/Phage Antibody Discovery - Protein Sciences

Surrozen South San Francisco , CA 94080

Posted 2 months ago

Surrozen is a biotechnology company focused on discovering and developing novel regenerative medicines with a focus on unlocking the powerful self-renewal properties of the body through specific control of the Wnt signaling pathway.

Surrozen was founded by five leading-edge scientists: K. Christopher Garcia, Ph.D., Roel Nusse, Ph.D. and Calvin Kuo, M.D., Ph.D. from Stanford University; Claudia Janda, Ph.D. from the Princess Maxima Center for Pediatric Oncology; and Hans Clevers, M.D, Ph.D. from the Hubrecht Institute and Princess Maxima Center. Each has conducted extensive research on Wnt signaling, with findings that together shape Surrozen's technology and approach to therapeutic development.

The Scientist/Sr. Scientist, In Vivo/Phage Antibody Discovery within the Protein Sciences Group is a great opportunity for experienced scientists to lead antibody discovery efforts using technologies including phage display and in vivo antibody discovery with single B cell cloning or immune display techniques to contribute to Surrozen's therapeutic pipeline.

  • Ph.D. in Molecular Biology, Immunology, or related life science field (or equivalent) with 3+ years experience with antibody discovery in biotechnology and/or pharma

  • Experience with molecular biology techniques such as E. coli transformation and cultivation, DNA extraction, enzyme digestion and gel electrophoresis experience

  • Ability to work independently while also contributing to project teams to discover potential therapeutic candidate antibodies as well as discovery antibodies for research related efforts

  • Candidates with hands-on experience with phage display, single B cell cloning, or immune display technologies highly desirable

  • Proficiency working with DNA analysis software programs such as Snapgene or their equivalent and with Microsoft Office (Word, Excel, PowerPoint)

  • Maintain a detailed and well-organized record of experiments in an electronic notebook

  • Preparation of technical reports, summaries and detailed protocols, and contribute to company reports as requested

  • Team player, committed to success and getting the job done well in a highly dynamic environment

  • Troubleshoot instrumentation or software issues and recommend solutions to meet objectives.

  • Strong interpersonal skills

  • Clear and effective written and verbal communication skills

  • Reliable availability for limited weekend work


  • Discover antibodies against challenging targets using phage display technologies, single B cell cloning, and high-throughput screening methods (ELISA/FACS)

  • Work closely with the Antigen Generation Group to design complex immune tolerance breaking strategies and other next generation technologies for in vivo antibody discovery campaigns

  • Work closely with the Protein:Protein Interactions Group to use HTP screening technologies (i.e., Surface Plasmon Resonance and Bio-Layer Interferometry) to identify lead antibody candidates

  • Utilize cloning and PCR methodologies including restriction digests, Gibson assembly, vector and primer design in antibody discovery campaigns

  • Work with other members of Protein Sciences to incorporate automation and liquid handling technologies in antibody discovery campaigns

  • Perform PCR, DNA mini-, midi-, maxi-prepping procedures

  • Maintain and archive DNA clones and bacterial glycerol stocks

  • We offer a dynamic start-up environment and a collaborative, passionate team

  • Excellent benefits, including competitive employer contributions

  • Sock options

  • Paid vacation, sick time and holidays

  • Shuttle service to/from Caltrain, BART and the South San Francisco Ferry

  • State-of-the-art research facility and onsite gym (see the amenities available at The Cove:

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Scientist/Sr. Scientist, In Vivo/Phage Antibody Discovery - Protein Sciences